We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of quinine therapy on plasma glucose and plasma insulin levels in pregnant women infected with Plasmodium falciparum malaria in Gezira state.
- Authors
Elbadawi, N. E. E.; Mohamed, M. I.; Dawod, O. Y.; Ali, K. E.; Daoud, O. H.; Ali, E. M.; Ahmed, E. G. E.; Mohamed, A. E.
- Abstract
To determine if quinine has a metabolic effect during treatment of severe or complicated malaria, we studied its effects on plasma glucose and plasma insulin levels in 150 pregnant women with malaria referred to Madani maternity teaching hospital, Gezira state and 50 healthy pregnant controls. Levels were determined at baseline (day 0) before the start of quinine treatment, after 2 days of treatment (2 hours after the 4th dose) and after 7 days of treatment (day 8). There was a statistically significant increase in plasma insulin concentrations during the quinine infusion and fall in plasma glucose concentration (P < 0.001). Quinine administered at the recommended dose and rate can disrupt plasma glucose homeostasis although it is still the drug of choice for severe and complicated malaria in Sudan.
- Subjects
SUDAN; DRUG therapy for malaria; ACADEMIC medical centers; ANALYSIS of variance; BLOOD sugar; INSULIN; MALARIA; QUININE; STATISTICAL hypothesis testing; STATISTICS; DATA analysis; CROSS-sectional method; DATA analysis software; PHARMACODYNAMICS; PREGNANCY; THERAPEUTICS
- Publication
Eastern Mediterranean Health Journal, 2011, Vol 17, Issue 9, p697
- ISSN
1020-3397
- Publication type
Academic Journal
- DOI
10.26719/2011.17.9.697