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Title

Clinico-pathological profile of acute promyelocytic leukaemia at Al-Amal oncology-haematology centre, Qatar.

Authors

Ibrahim, F. A.; Yassin, M. A.; El-Ayoubi, H. R.; Alhijji, I. A.; Albinali, A. S.; Almansour, S. M.; Qafoud, F. M.

Abstract

This cases series describes the profile of adult patients with acute promyelocytic leukaemia (APL) at a referral hospital in Qatar. Of 34 acute myeloid leukaemia (AML) cases diagnosed, 11 (32%) were classified as APL. Disseminated intravascular coagulation was common at presentation (91%). Severe thrombocytopenia was seen in 73%, leukocytosis in 55% and severe anaemia in 45%. Only 2 patients were of the classic hypergranular type. In the remaining 9 patients, 3 morphological subtypes were recognized: microgranular variant (6 patients), hyperbasophilic (2 patients) and regular nuclear outline M3r (1 patient). Translocation t(15;17) was detected in 63% of cases. APL constitutes a high proportion of AML cases in Qatar, with considerable morphological heterogeneity and a predominance of APL variants with unfavourable presenting features.

Subjects

QATAR; ANALYSIS of variance; ANEMIA; BONE marrow examination; CANCER treatment; CYTOGENETICS; DISSEMINATED intravascular coagulation; FLOW cytometry; IMMUNOPHENOTYPING; LEUKOCYTE disorders; THROMBOCYTOPENIA; SPECIALTY hospitals; ACUTE myeloid leukemia

Publication

Eastern Mediterranean Health Journal, 2010, Vol 16, Issue 9, p958

ISSN

1020-3397

Publication type

Academic Journal

DOI

10.26719/2010.16.9.958