Title: GLUT4 Translocation Active Flavonoids from Caragana jubata.
Authors: Ping Song; Huazhen Li; Pengxin Liu; Tongqing Li; Yan Guo; Ping Zhao; Shiwen Kang; Xinzhou Yang
Abstract: Two new isoflavones, caraganin E (1) and caraganin F (2), were purified from 75% ethanolic extract of Caragana jubata roots, in company with ten known compounds. The chemical structures of two novel isoflavones were elucidated by NMR, HR-ESIMS and circular dichroism (CD). GLUT4 translocation activity was tested in L6 cells for all isolated compounds. Among them, compound 5 exhibited the best activity, increasing the fluorescence intensity by 3.25 folds. The results of the exploration may help us understand the chemotaxonomic variety of natural products in Caragana jubata and enhance the diversity of flavonoids.
Subjects: CIRCULAR dichroism; NATURAL products; CHEMICAL structure; FLAVONOIDS; FLUORESCENCE; ISOFLAVONES
Publication: Records of Natural Products, 2024, Vol 18, Issue 6, p610
ISSN: 1307-6167
Publication type: Academic Journal
DOI: 10.25135/rnp.484.2408.3301

GLUT4 Translocation Active Flavonoids from Caragana jubata.

Ping Song; Huazhen Li; Pengxin Liu; Tongqing Li; Yan Guo; Ping Zhao; Shiwen Kang; Xinzhou Yang