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- Title
GLUT4 Translocation Active Flavonoids from Caragana jubata.
- Authors
Ping Song; Huazhen Li; Pengxin Liu; Tongqing Li; Yan Guo; Ping Zhao; Shiwen Kang; Xinzhou Yang
- Abstract
Two new isoflavones, caraganin E (1) and caraganin F (2), were purified from 75% ethanolic extract of Caragana jubata roots, in company with ten known compounds. The chemical structures of two novel isoflavones were elucidated by NMR, HR-ESIMS and circular dichroism (CD). GLUT4 translocation activity was tested in L6 cells for all isolated compounds. Among them, compound 5 exhibited the best activity, increasing the fluorescence intensity by 3.25 folds. The results of the exploration may help us understand the chemotaxonomic variety of natural products in Caragana jubata and enhance the diversity of flavonoids.
- Subjects
CIRCULAR dichroism; NATURAL products; CHEMICAL structure; FLAVONOIDS; FLUORESCENCE; ISOFLAVONES
- Publication
Records of Natural Products, 2024, Vol 18, Issue 6, p610
- ISSN
1307-6167
- Publication type
Academic Journal
- DOI
10.25135/rnp.484.2408.3301