Drug-induced eosinophilia.

Rauscher, Christine; Freeman, Allison

Background: Drug reactions have been associated with increased blood eosinophil levels. Objective: To review clinical characteristics, the diagnosis, and the management of drug-induced eosinophilia. Methods: Pertinent articles were selected and reviewed in relation to a case presentation of drug-induced eosinophilia. Results: A case of asymptomatic eosinophilia in the setting of acetylsalicylic acid (aspirin) use was presented, followed by discussion of the clinical characteristics, diagnosis, and management of drug-induced eosinophilia. Clinical pearls and pitfalls were reviewed for the practicing allergist, clinical immunologist, and fellow-in-training. Conclusion: Drug-induced eosinophilia is a diagnosis of exclusion. Although most cases of drug-induced eosinophilia are asymptomatic, one study showed an increased rate of hypersensitivity reactions in patients with higher eosinophil counts and earlier onset of eosinophilia.

EOSINOPHILIA; IDIOSYNCRATIC drug reactions; TAKAYASU arteritis; ASPIRIN; AMIODARONE

Allergy & Asthma Proceedings, 2018, Vol 39, Issue 3, p252

1088-5412

Academic Journal

10.2500/aap.2018.39.4120