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- Title
Hypereosinophilic syndrome.
- Authors
Noh, Heung R.; Magpantay, Gil G.
- Abstract
Background: Hypereosinophilic syndrome (HES) is a myeloproliferative disorder characterized by persistent eosinophilia associated with multiple organ damage. Objective: To increase awareness of the rare but potentially life-threatening disease and to provide a brief overview of the clinical presentation, diagnosis, and management of HES. Methods: Pertinent data from the patient's clinical course was incorporated with salient articles on the topic. Results: A case of HES is presented, followed by discussion of the clinical characteristics, diagnosis, and management. Clinical pearls and pitfalls are emphasized for the practicing allergist, clinical immunologist, and fellow-in-training. Conclusion: A diagnosis of HES should be considered in patients with an absolute eosinophil count of >1500 cells/μL documented on two occasions at least 1 month apart, and/or in those with pathologic confirmation of tissue hypereosinophilia. The decision to treat HES should be guided by both the clinical presentation and results of laboratory and mutational analysis.
- Subjects
HYPEREOSINOPHILIC syndrome; MYELOPROLIFERATIVE neoplasms; EOSINOPHILIA
- Publication
Allergy & Asthma Proceedings, 2017, Vol 38, Issue 1, p78
- ISSN
1088-5412
- Publication type
Academic Journal
- DOI
10.2500/aap.2017.38.3995