VITAMIN D AND THIOL-DISULFIDE HOMEOSTASIS LEVELS IN POST-MENOPAUSAL WOMEN WITH OVERACTIVE BLADDER SYNDROME.

Ustundag, Yasemin; Karlibel, Iknur Aykurt; Sambel, Murat; Ozturk, Murat; Satir, Atilla; Yolgosteren, Elif; Neselioglu, Salim; Erel, Ozcan

Background: This study aimed to find a relationship between vitamin D concentration and thiol-disulfide homeostasis in the pathophysiology of overactive bladder (OAB) syndrome in postmenopausal women. Methods: A total of 76 postmenopausal women, referred for routine controls, were recruited between January and March 2018 to participate in this study. Participants with an overactive bladder questionnaire (OAB-q) score of >11 (n = 34) were included in the OAB syndrome group, while those with a score of <5 (n = 42) were included in the control group. Serum total antioxidant capacity, ischemia-modified albumin, C-reactive protein, 25-hydroxy vitamin D levels, and thiol-di sulfide homeostasis were measured. Results: Patients with OAB syndrome had waist circumferences of 106 ± 11 cm, and their body mass indexes (BMIs) were 30.8 ± 4.8 kg/m2. The control groups' waist circumferences were 102 ± 11 cm and their BMIs were 28.9 ± 4.3 kg/m2 (p = 0.069 and p = 0.098, respectively). The level of vitamin D in the control group was 33.7 (IQR: 30.7) nmol/L and 27.0 (IQR: 27.5) nmol/L (p = 0.081) in the OAB syndrome group. Conclusions: We were not able to demonstrate with certainty any significant relationships between serum 25-hydroxy vitamin D levels and th iol-disu If ide homeostasis parameters and OAB syndrome.

OVERACTIVE bladder; POSTMENOPAUSE; VITAMIN D; OXIDANT status; HOMEOSTASIS; WAIST circumference

Journal of Medical Biochemistry, 2020, Vol 39, Issue 1, p1

1452-8258

Academic Journal

10.2478/jomb-2019-0003