PROTECTIVE ROLE OF VITAMIN C AGAINST TOXIC INDOOR POLLUTANTS RELEASED FROM PYRETHROID BASED MOSQUITO COIL ON A RAT MODEL: A HISTOPATHOLOGICAL STUDY.

Singh, Raghvendra; Singh, Heena; Ranjana; Manik, Punita; Diwan, Rakesh Kumar; Kumari, Sangeeta

Mosquitoes are the deadliest animals in the world because of their ability to carry and spread disease to humans and thus causes millions of deaths every year. India is struggling every year to get rid of deadly diseases caused by these mosquitoes like malaria, chickungunya and dengue etc. Pyrethroid based mosquito coils (PBMC) are most common used mosquito repellents in India because of its effectiveness, low cost and easy availability. This study is an attempt to delineate the effect of inhaling mosquito coil smoke on the histopathological changes in heart, lung and kidney of albino wistar rats along with possible protective role of vitamin C. A total of thirty-six (36) adult albino rats of the Wistar strain are randomly divided into three groups of twelve rats in each. Group I served as control (no exposure to mosquito coil smoke). Group II and III received mosquito coil smoke 8 hours a day, 7 days a week for 12 weeks. Group III rats are co-administered with oral supplementation of Vit. C (20 mg/kg body weight) once in a day for the same time period. At the end of each experimental period, rats are sacrificed, organs are removed, and formalin preserved for histopathological study. Each specimen is examined under 5x and 10x for any histological changes. These findings suggest that inhaling mosquito coil smoke cause significant histological damage in rats' lung and kidney but least effect on their heart. this study also demonstrate the protective effect of vitamin c in group III rats. Pyrethroid based mosquito repellents are toxic to our organ system so there should be vigorous effort to replace them with other nontoxic methods. Vitamin C has a protective effects against the damage caused by these Pyrethroid based mosquito coil (PBMC), so proper supplementation should be given to affected individuals.

INDIA; VITAMIN C; MOSQUITO vectors; MOSQUITOES; POLLUTANTS; RATS; BODY weight; AEDES aegypti; SPRAGUE Dawley rats

Era's Journal of Medical Research, 2020, Vol 7, Issue 1, p40

2348-9839

Academic Journal

10.24041/ejmr2020.7