Objective: In this study, we aimed to evaluate the distribution and mean values of fetal nuchal translucency (NT) in singleton pregnancies with low risk in Manisa city. It was also aimed to evaluate relationship between NT values and week of gestation, crown-rump length (CRL), parity and maternal weight. Methods: A total of 351 singleton pregnancy cases who admitted to our perinatology clinic in between March 2013 and May 2014 for screening at 11-14 weeks of gestation were included in the study. Fetal NT, CRL measurements, week of gestation, maternal weight and parity were evaluated. Three hundred and fifty-one cases that were included in the study were separated into four groups according to their CRL measurements: Those with CRL between 45 and 54 mm were determined as Group 1 (n=62), those with CRL between 55 and 64 mm were determined as Group 2 (n=133), those with CRL between 65 and 74 mm were determined as Group 3 (n=115), and those with CRL between 75 and 84 mm were determined as Group 4 (n=41). The groups were compared in terms of maternal age and mean NT value. Results: Mean age of the cases was 28.76±5.51, mean week of gestation was 12.29±0.69, mean CRL value was 63.69±9.07 mm, and mean NT value was 1.23±0.48 mm. No significant difference was observed among the groups in terms of maternal age and NT measurement (p=0.817 and 0.072, respectively). In the correlation analysis, it was seen that NT value was significantly correlated with CRL (r=0.232; p=0.001) and week of gestation (r=0.203; p=0.001) statistically. No relationship was found between NT and gravida, parity and maternal age. Conclusion: First trimester screening is a method becoming more common in terms of prenatal diagnosis. Fetal NT is a part of this screening procedure. Fetal NT measurement should be carried out in accordance with the standards and pregnancy management should be planned according to the algorithms.