Prediction of small for gestational age neonates in twin pregnancies by first trimester maternal serum PAPP-A and free β-hCG.

Şanlı, Dilek Beker; Kartkaya, Kazım; Mutlu, Fezan Şahin

Objective: To determine the association between first trimester serum markers and pregnancy complications such as SGA and preterm delivery in twin pregnancies. Methods: The study included 86 multiple pregnancies. Total study population divided into three study groups as follows: very preterm pregnancies (<32 weeks), preterm pregnancies (≥32 and <37 weeks) and term pregnancies (≥37 weeks). PAPP-A, free β-hCG and birth weight percentile differences between study groups were tested for statistical significance. Results: According to birth weight percentiles, there was statistically significant difference between very preterm-preterm and very preterm-term groups (p<0.05). PAPP-A and free β-hCG medians for each group were not significantly different (p>0.05). PAPP-A levels below 5th percentile were associated with low birth weight percentiles in twin pregnancies (OR=0.968, 95% CI for OR 0.945-0.992, p=0.008). However, significant association with free β-hCG was not found regarding SGA. Conclusion: First trimester maternal serum PAPP-A can be used to predict pregnancy complications like SGA in twin pregnancies.

PREGNANCY complications; NEONATAL death; MULTIPLE pregnancy; FIRST trimester of pregnancy; GESTATIONAL age; BLOOD proteins; PREMATURE labor; RESPIRATORY distress syndrome

Perinatal Journal / Perinatoloji Dergisi, 2014, Vol 22, Issue 3, p152

1300-5251

Academic Journal

10.2399/prn.14.0223009