Objective: Pregnancy is an important risk factor for growth of choledochal stones. Since choledocholithiasis encountered during pregnancy, which is also a possible cause of pancreatitis and cholangitis, may be the reason for serious morbidity and mortality both for the mother and the fetus, it should be treated. In this article, the results and reliability of endoscopic retrograde cholangiopancreatography (ERCP) application on a pregnant woman to whom ERPC is applied because of choledocholithiasis are presented. Case: Patient who was 21 years old, giving two living births of three gravidas, applied in her 21 weeks of gestation with the complaints of nausea, vomiting and backache. After examinations, she was diagnosed as choledocholithiasis. The ERCP applied patient has delivered a healthy baby at term following a pregnancy with no problems. Conclusion: ERCP is the first procedure that will be preferred in the treatment of choledocholithiasis in pregnancy with the right indications provided that proper precautions have been taken. Possible harmful effects of ionized radiation on fetus during fluoroscopy should be minimalized by giving in short periods and low doses.