The roles of beta-human chorionic gonadotropin, creatinine and urea in vaginal washing fluid in the diagnosis of premature rupture of membranes.

Tı¤lı, Alihan; Kurt, Sefa; Kopuz, Aycan

Objective: In this study, we aimed to test the roles and safety of urea, creatinine and beta-human chorionic gonadotropin for the diagnosis of premature rupture of membranes (PROM) by considering that fetus urine is significant for amnion formation, urea and creatinine concentrations being high in fetus urine and beta-human chorionic gonadotropin (beta-HCG) concentrations are high in amniotic fluid. Methods: This study was conducted on 150 pregnant women who referred to the obstetrics and gynecology clinic. The study group consisted of 75 pregnant women between 27 and 42 weeks of gestation whose diagnosis of membrane rupture was confirmed and amniotic fluid came apparently. The control group consisted of 75 pregnant women between 27 and 42 weeks of gestation who did not have complaints of water break and vaginal discharge, and whose membrane rupture was ruled out. After administering 10 cc 0.9% NaCl to posterior fornix by sterile injector, a total of 6 cc washing fluid was collected. Urea, creatinine and human chorionic gonadotropin were examined on the same day on collected fluid and both groups were compared statistically. Results: Beta-HCG, urea and creatinine values in vaginal washing fluid of the cases with premature rupture of membranes were statistically and significantly high compared to the control group (p<0.05). When designating cut-off value of beta-HCG in vaginal bleeding fluid as 50 mIU/dL, sensitivity, specificity, and positive and negative predictive values were 85.33%, 93.33%, 92.75% and 86.41%, respectively. Conclusion: In our study, we obtained the most valuable data in premature rupture of membranes (PROM) by beta-HCG values in vaginal washing fluid. Similar results were obtained by other PROM diagnosis tests currently used such as insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha microglobulin and prolactin in the vaginal fluid. When these tests are compared, it is seen that beta- HCG test in vaginal fluid is cheaper and easier, and thus it becomes more practicable.

CHORIONIC gonadotropins; CREATININE; UREA; PREMATURE rupture of fetal membranes; PREGNANCY complications; AMNIOTIC liquid; PROLACTIN

Perinatal Journal / Perinatoloji Dergisi, 2014, Vol 22, Issue 3, p133

1300-5251

Academic Journal

10.2399/prn.14.0223005