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- Title
438-P: Contribution of Hypertriglyceridemia to Cardiovascular Disease in Korean Women: A Nationwide Population-Based Study
- Authors
CHOE, HUN JEE; MOON, MIN KYONG; KOO, BO KYUNG
- Abstract
Introduction: The independent effect of serum triglyceride (TG) level on the development of cardiovascular disease (CVD) has been inconclusive, which might be due to heterogeneity of study populations. We aimed to evaluate the effect of TG level on CVD and mortality in Korean women with stratification according to the menopausal status, diabetes mellitus (DM) or LDL cholesterol level (LDL-C). Method: We investigated Korean women aged 40-69 years who underwent health examination in 2009 and were followed up until 2018 using nationwide claim data covering 97.0% of the Korean population. The subjects were divided into four groups according to TG quartiles (Q): Q1 Results: Among 2,208,347 women, primary outcome occurred in 62,255 (2.8%) subjects. As TG levels increased, the event rate of primary outcome increased in both premenopausal and postmenopausal women in the fully adjusted model (hazard ration [HR] per 1 Q, 1.10 [95% confidence interval (CI), 1.08-1.12] and 1.08 [95% CI, 1.07-1.09], respectively), which was maintained on further stratification according to DM or LDL-C (p Conclusion: TG is an independent prognosticator in the development of CVD in the Korean women aged 40-69 years. The dose-response relationship is more significant in patients without diabetes when LDL-C DisclosureH. Choe: None. M. Moon: None. B. Koo: None.
- Publication
Diabetes, 2021, Vol 70, Issue Supplement_1
- ISSN
0012-1797
- DOI
10.2337/db21-438-p