The author comments on the study "SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function." She discusses the functions of the SGLT-2, a member of the sodium glucose transporter (SGLT) family of transmembrane proteins. She explores the physiological effects of deleting SGLT-2. She addresses the inability to achieve the complete blockade of renal glucose reabsorption with selective SGLT-2 inhibition.