Synthesis and characterization of new 2-amino-4-(3,4-dihydro- -7-methoxy-2,2-dimethyl-2H-benzopyran-6-yl)-6-(substituted phenyl)pyrimidines and their bioevaluation.

Murthy, Yellajyosula Lakshmi Narasimha; Suhasini, Kilaru Padma; Jha, Anjali

A series of eight novel 2-amino-4-(3,4-dihydro-7-methoxy-2,2-dimethyl- 2H-benzopyran-6-yl)-6-(substituted phenyl)pyrimidines were designed and synthesized by utilizing benzene-1,3-diol as the starting material. The structures of the isolated products (6a--h) were established through ¹H-NMR, 13C-NMR, and FT-IR spectroscopic techniques and elemental analysis. The antimicrobial properties of the synthesized compounds were screened against gram positive (Bacillus pumilus, Bacillus subtilis and Streptococcus faecalis), gram negative bacteria (Enterococcus faecalis, Escherchia coli and Proteus vulgaris) and fungi (Pencillium expansum, Aspergillus niger and Candida albicans) using ampicillin and ketoconazole as reference compounds. Most of the compounds showed moderate to high antibacterial and antifungal activities against the studied strains, with inhibition zones between 8 and 30 mm.

CHEMICAL synthesis; PYRIMIDINE derivatives; SCHMIDT reaction; CHALCONES; BENZOPYRANS; GRAM-negative bacteria

Journal of the Serbian Chemical Society, 2012, Vol 77, Issue 7, p859

0352-5139

Academic Journal

10.2298/JSC110923008M