Photo-recall cutaneous reaction to gemcitabine.

D'Adamio, Simone; Talamonti, Marina; Bianchi, Luca; Galluzzo, Marco

Cutaneous reactions attributable to chemotherapy too often result in a modification of patients' treatment plan. Most treatments remain largely unproven: only small series or case reports may indicate possible treatment options. Main observations: We reported the case of a male patient with gemcitabine-induced skin reaction occurred after a cycle of therapy with carboplatin plus gemcitabine following a 21 days' schedule. The patient came to our attention for an extensive, well-demarked, erythematous, lilaceous, warm indurated lesion, covering his dorsal faces of both hands, without systemic symptoms. Clobetasol propionate 0.05% ointment was prescribed as main therapy, followed by a cream containing boswellic acids. Conclusions: It is presumable that similar dermatological lesions consist in a 'radiation recall reaction' whereby an inflammatory reaction occurs in the area previously treated with radiotherapy or affected by a sun-burn in the past. In our patient, interestingly, there is no history of radiotherapy even if there is history of strong sun exposure. Pharmacological antiinflammatory effect due to boswellic acids was studied and relieved only in radiation-induced dermatitis, and even if larger studies would have been set in order to have more effective results, it would be useful to study application of this compound in chemotherapy-induced cutaneous adverse reactions too.

CUTANEOUS leishmaniasis; SKIN inflammation

Archive of Clinical Cases, 2017, Vol 4, Issue 4, p191

2360-6975

Academic Journal

10.22551/2017.17.0404.10113