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- Title
Synthesis and Biological Evaluation of 1-(6-bromobenzo [d]thiazol-2-yl)-2- (disubstituted methylene) hydrazine derivatives.
- Authors
Sharma, Neetesh Kumar; Bhadauria, Raghvendra Singh
- Abstract
Synthesis of a series of various 1-(6-bromobenzo[d]thiazol-2-yl)-2-(disubstitutedmethylene)hydrazine derivatives (7a-7e)have been done. Synthesis of a series of intermediates (3 and 5) have been also done, 6-bromo-1,3-benzothiazole-2-amine (3), 2-hydrazino-6-bromo-1, 3- benzothiazole (5) and final product (7a-7e), 1-(6-bromobenzo[d]thiazol-2-yl)-2-(diphenylmethylene) hydrazine (7a), 1-(6-bromobenzo [d]thiazol-2-yl)-2-(propan-2-ylidene) hydrazine (7b), (E)-2-(butan-2-ylidene)-1-(6-bromobenzo[d]thiazol-2-yl)hydrazine (7c), (Z)-1-(6- bromobenzo[d]thiazol-2-yl)-2-(cyclohexylmethylene) hydrazine (7d), 2-(6-bromobenzo[d]thiazol-2-yl)-1-(7,7- dimethylbicyclo [2.2.1] heptan- 2-ylidene)hydrazine (7e). Spectral analysis of all intermediates and final products has been done by IR and NMR. After spectral analysis, antibacterial activity has been screened against S. aurius and E. coli bacterias.
- Subjects
HYDRAZINE derivatives; BIOSYNTHESIS; HYDRAZINE; INTERMEDIATE goods; CHALCONE
- Publication
Journal of Drug Delivery & Therapeutics, 2019, Vol 9, Issue 4A, p577
- ISSN
2250-1177
- Publication type
Academic Journal
- DOI
10.22270/jddt.v9i4-A.3520