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- Title
Synthesis and Biological Evaluation of pyrazole derivatives containing ethanone skeleton as Anti-inflammatory agents.
- Authors
Khushboo, Mishra; Jain S. K.; Singour P. K.
- Abstract
Current research had focused on the synthesis of the novel pyrazole ethanone linked compounds with improved biological activity. In this synthetic process 1st step was to synthesize the intermediate chalcone and 2nd step was the synthesis of final compound pyrazole derivative containing ethanone moiety. This procedure is the type of cyclization reaction using proton transfer mechanism. By using this method 8 derivatives synthesized. After synthesis these were subjected to identification tests by using various methods like melting point study, thin layer chromatography, solubility study and characterization by using UV, IR and NMR Spectroscopy.
- Subjects
PYRAZOLE derivatives; BIOSYNTHESIS; CHALCONE; ISOXAZOLES; ANTI-inflammatory agents; PROTON transfer reactions; THIN layer chromatography
- Publication
Journal of Drug Delivery & Therapeutics, 2019, Vol 9, Issue 3, p40
- ISSN
2250-1177
- Publication type
Academic Journal
- DOI
10.22270/jddt.v9i3.2736