Phenytoin Induced Cerebral Atrophy: A Case Report.

Linggi, Celeste; Mathews, Anit; Mopidev, Rasi; Nyamagoud, Sanat Kumar B.; D. S., Usha

Phenytoin is the most common drug prescribed in patient diagnosed with seizure. Cerebral atrophy is an observed complication in phenytoin exposed patients. The side effects related to phenytoin administration include sedation, dizziness, swaying, rash and gum hypertrophy. In the following case report a 50-year-old male patient with complaints of poor response to oral commands, slurred speech, limited upper limb movements and neck rigidity, the patient is a known epileptic since 1 year on prescription and is alcoholic. Upon CT scan of brain, the impression was mild diffuse cerebellar atrophy probably due to long term phenytoin use. Hence frequent phenytoin level monitoring in patient prescribed with the same is mandatory.

CEREBRAL atrophy; PHENYTOIN; COMPUTED tomography; PATIENT monitoring; BRAIN imaging; SPEECH apraxia

Journal of Drug Delivery & Therapeutics, 2022, Vol 12, Issue 5, p1

2250-1177

Academic Journal

10.22270/jddt.v12i5.5640