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- Title
Formulation and Evaluation of Self Nano Emulsifying Drug Delivery System of Raloxifene Hydrochloride.
- Authors
Gayathri, T.; Ramana, M. Venkata; Rao, N. Rama
- Abstract
Raloxifene hydrochloride (RLX) is a selective Estrogen-receptor modulator used to treat osteoporosis as well as breast and endometrial cancer prevention. The bioavailability of RLX is only 2% due to substantial pre-systemic clearance. The goal of this research was to customise and characterise RLX-loaded self-nanoemulsifying drug-delivery systems (SNEDDS) by using bioactive excipients that impact drug metabolism. The droplet size, zeta potential and drug content determination of optimized formulation (F-06) was found to be 147.5 nm, -28.8, 99.67% respectively. The drug release study from the nano formulation was studied in Phosphate buffer 6.8 for all the formulations F1,F2,F3,F4,F5,F6 and F7. The optimized formulation was found to be F6.
- Subjects
DRUG delivery systems; SELF-evaluation; RALOXIFENE; BREAST cancer; DRUG metabolism
- Publication
Journal of Drug Delivery & Therapeutics, 2021, Vol 11, Issue 4, p16
- ISSN
2250-1177
- Publication type
Academic Journal
- DOI
10.22270/jddt.v11i4.4857