Title: Formulation and Evaluation of Self Nano Emulsifying Drug Delivery System of Raloxifene Hydrochloride.
Authors: Gayathri, T.; Ramana, M. Venkata; Rao, N. Rama
Abstract: Raloxifene hydrochloride (RLX) is a selective Estrogen-receptor modulator used to treat osteoporosis as well as breast and endometrial cancer prevention. The bioavailability of RLX is only 2% due to substantial pre-systemic clearance. The goal of this research was to customise and characterise RLX-loaded self-nanoemulsifying drug-delivery systems (SNEDDS) by using bioactive excipients that impact drug metabolism. The droplet size, zeta potential and drug content determination of optimized formulation (F-06) was found to be 147.5 nm, -28.8, 99.67% respectively. The drug release study from the nano formulation was studied in Phosphate buffer 6.8 for all the formulations F1,F2,F3,F4,F5,F6 and F7. The optimized formulation was found to be F6.
Subjects: DRUG delivery systems; SELF-evaluation; RALOXIFENE; BREAST cancer; DRUG metabolism
Publication: Journal of Drug Delivery & Therapeutics, 2021, Vol 11, Issue 4, p16
ISSN: 2250-1177
Publication type: Academic Journal
DOI: 10.22270/jddt.v11i4.4857

Formulation and Evaluation of Self Nano Emulsifying Drug Delivery System of Raloxifene Hydrochloride.

Gayathri, T.; Ramana, M. Venkata; Rao, N. Rama