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- Title
Repurposable Drug Candidates are Potential Therapeutic Target against Global SARS-CoV-2 Crisis.
- Authors
Rahman, Md. Siddikur; Mina, Fahmida Begum; Das, Sabuj; Billah, Mutasim; Karmakar, Sumon; Khan, Alam; Akhtar, Sharmin; Acharjee, Uzzal Kumar; Hasan, Md. Faruk
- Abstract
This review provides a pharmacological approach to combat Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) based on two comprehensive denominations which could be specifically intended for viral replication process by either inhibiting essential genomic viral enzymes or preventing viral entry to human cells. These denominations focused on immune therapies either to improve innate antiviral immune responses or to reduce impairment triggered by underactive inflammatory reactions. A variety of drug candidates are available which can inhibit SARS-CoV-2 infection and replication, comprising serine protease inhibitors: Transmembrane Orotease/Serine Subfamily member 2 (TMPRSS2), camostat mesylate, nafamostat mesylate, and angiotensin-converting enzyme inhibitors. This review is also concerned with identifying drugs and ongoing clinical trials with their mechanisms of action against SARS-CoV-2. Chloroquine and hydroxychloroquine, monoclonal antibody, off-label antiviral drugs, nucleotide analog remdesivir and broad-spectrum antiviral drugs also could be used as inhibitors of SARS-CoV-2. Moreover, non-steroidal anti-inflammatory drugs (NSAIDs), dexamethasone, and antiviral phytochemicals that are currently reachable, can prevent SARS-CoV-2 pandemic morbidity and mortality.
- Subjects
SARS-CoV-2; HIV protease inhibitors; OFF-label use (Drugs); VIRUS-induced enzymes; CLINICAL drug trials; ACE inhibitors; ANTIVIRAL agents
- Publication
Journal of Drug Delivery & Therapeutics, 2020, Vol 10, p209
- ISSN
2250-1177
- Publication type
Academic Journal
- DOI
10.22270/jddt.v10i5-s.4343