Results
Title

Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial.

Authors

AkbariRad, Mina; Khorasani, Zahra Mazloum; Beizae, Behnam; Ayatollahi, Hossein; Emadzadeh, Maryam; Sarabi, Mehrdad; Saeedi, Nikoo; Nekooei, Negar

Abstract

Background: The current study intends to assess the impact of oral selenium intake on anti-Tg antibody in individuals with autoimmune hypothyroidism. Methods: In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; One group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software. Results: After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant. Conclusion: Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group.

Subjects

RANDOMIZED controlled trials; SELENIUM; HYPOTHYROIDISM; IMMUNOGLOBULINS

Publication

Caspian Journal of Internal Medicine, 2024, Vol 15, Issue 2, p340

ISSN

2008-6164

Publication type

Academic Journal

DOI

10.22088/cjim.15.2.340