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- Title
Relationship Study of The Verified H uman Epidermal Growth Factor Receptor 2 Amplification with Other Tumor Markers and Clinicohistopathological Characteristics in Patients with Invasive Breast Cancer, Using Chromogenic In Situ Hybridization.
- Authors
Sarli, Abdolazim; Mozdarani, Hossein; Rakhshani, Nasser; Mozdarani, Sohail
- Abstract
Human epidermal growth factor receptor 2 ( HER-2 ), as a crucial factor involved in about 20% of breast cancer cases, is one of the most reliable tumor markers to determine prognosis and therapeutic trend of this disease. This marker is generally assessed by immunohistochemistry (IHC) technique. In the cases that result of IHC test cast doubt (+2), the test should be repeated or validated by applying in situ hybridization techniques, like chromogenic in situ hybridization (CISH). In this regard, the goal of current study was to figure out the link between different clinicopathological characteristics of patients suffering from invasive breast cancer, using tumor markers, hormone receptor (HR) and HER-2. Comparing IHC and CISH techniques for evaluating diagnostic value and usefulness of HER-2 were also the other objective of this study.
- Publication
Cell journal, 2019, Vol 21, Issue 3, p322
- ISSN
2228-5806
- Publication type
Journal Article
- DOI
10.22074/cellj.2019.6219