Dynamic capabilities refer to an organization’s capacity to purposefully create, expand, or change its resource base. The gas industry of each country plays an important role in its economy and growth. Further, we are in an era where rapid global changes and technological innovations occur, and gas refineries are not unaffected by these changes. Thus, the objective of this research is to identify dynamic capabilities within knowledge-based companies in the gas-refining industry. This study employs a mixed-method approach to develop a model of dynamic capabilities specific to knowledge-based gas-refining enterprises. By analyzing 54 articles through a meta-synthesis method and conducting semi-structured interviews with 12 experts in this field, we identified the components of dynamic capabilities through thematic analysis. Then, the factors were evaluated using confirmatory factor analysis, and a questionnaire was distributed to specialists, with all components being validated in the initial phase. This work utilized structural interpretive modeling (ISM) to develop the final model, and the corresponding questionnaire was completed by 15 managers of knowledge-based companies in Tehran.