Results
Title

Cytotoxic Activity of Thirteen Endemic and Rare Plants from Chaharmahal and Bakhtiari Province in Iran.

Authors

Emami, Seyed Ahmad; Kheshami, Shima; Ramazani, Elham; Akaberi, Maryam; Iranshahy, Milad; Kazemi, Seyed Mahammad; Tayarani-Najaran, Zahra

Abstract

Chaharmahal and Bakhtiari Province is one of the most important endemism states of the flora of Iran with a considerable plant species diversity. In the present study, the cytotoxic activity of 13 plant species grown in Chaharmahal and Bakhtiari have been evaluated on prostate (PC-3), breast (MCF-7), liver (HepG2), ovary (CHO), and melanoma (B16-F10) cancer cell lines. The cytotoxicity and apoptotic activity of methanol extracts was evaluated using resazurin reagent and flow cytometry of PI stained cells, respectively. Methanol extracts of Dionysia sawyeri, Stachys obtusicrena and Cicer oxyodon on CHO cell line (p <0.05) and D. sawyer and Linum album on B16/F10 cell line (p <0.05) showed significant cytotoxic effects and increased apoptosis. It is generally suggested that the plant extracts with low IC50 values are likely to be used as anti-cancer compounds in reducing cancer progression in scientific studies.

Subjects

IRAN; RARE plants; ENDEMIC plants; LIVER cells; PLANT species diversity; PLANT capacity; CHO cell; CELL lines; CHEMICAL plants

Publication

Iranian Journal of Pharmaceutical Research, 2019, Vol 18, Issue 4, p1912

Publication type

Academic Journal

DOI

10.22037/ijpr.2019.14665.12599