Results
Title

In-vitro Antibacterial and Antifungal Screening of Newly Synthesized Trifluoromethylated N-Heterocyclic ketenimines and 1 -aza butadiene Derivatives.

Authors

Ameri, Rosa Edris; Mohtat, Bita; Alipour, Eskandar; Rahimifard, Nahid; Mirza, Behrooz

Abstract

In our previous work, some trifluoromethylated ketenimines and 1 -aza butadienes derivatives from N- H heterocyclic compounds were synthesized, and their characteristics were confirmed by their spectroscopic data as introduced. In this research, the antifungal and antibacterial effects of newly synthesized compounds were evaluated. The antibacterial activity of compounds was studied against Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922, and Pseudomonas aeruginosa ATCC9027. Furthermore, their antifungal activity was monitored against Candida albicans ATCC10231. Disk Diffusion Agar test and minimum inhibitory concentration (MIC) methods were used as per the National Committee for Clinical Laboratory Standards (NCCLS) recommendations. The results showed that the ketenimines derivatives from 2-pyridinone and 4- quinazolinone have considerable antibacterial activity against Staphylococcus aureus and Escherichia coli standard strains. Trifluoromethylated ketenimines and 1- aza butadiene derivatives have no antibacterial effect on P. aeruginosa strain. Moreover, the trimethylated ketenimines and 1 -aza butadienes derivated from 4-quinazolinone showed acceptable antifungal activity against Candida albicans.

Subjects

KETENIMINES; ANTIFUNGAL agents; DISC diffusion tests (Microbiology); CANDIDA albicans; BUTADIENE; HETEROCYCLIC compounds; QUINAZOLINONES

Publication

Journal of Chemical Health Risks, 2023, Vol 13, Issue 1, p57

ISSN

2251-6719

Publication type

Academic Journal

DOI

10.22034/jchr.2021.1926711.1280