Results
Title

Evaluation of the antifungal effect of Badrashboo (Dracocephalum moldavica) essential oil and its interaction with Nystatin on some fungal strains.

Authors

Sheykhjan, Mitra Ghodsi; Fazlara, Ali; Hojjati, Mohammad; Behbahani, Behrooz Alizadeh

Abstract

Although chemical antifungal preservatives are often used in various food products, the use of these substances has been limited due to their harmful effects on human health and the environment. Researchers have recently sought to replace these chemical compounds with natural and less dangerous substances. In this regard, using essential oils of medicinal plants can be considered a suitable alternative due to fewer side effects. Therefore, in the present research, after preparing the Badrashboo plant from the fields of Golmarz village located near Urmia city and drying it, extracting the essential oil from the Badrashboo was carried out using a Clevenger, and the antifungal effect of Badrashboo essential oil on some important fungal strains with disc diffusion agar and well diffusion agar, minimum inhibitory concentration, minimum fungicidal concentration and the interaction of Badrashboo essential oil with Nystatin were performed. The results of disk diffusion agar and well diffusion agar tests showed that Badrashboo essential oil had a significant antifungal effect on all studied fungal strains. The results of the minimum inhibitory concentration of essential oil for strains of Saccharomyces cerevisiae, Candida albicans, Aspergillus niger, Fusarium solani, and Penicillium expansum were 8, 16, 2, 8, and 4 mg/mL, respectively. The minimum fungicidal concentration for the mentioned strains was 32, 64, 8, 16, and 32 mg/mL respectively. Also, the results of the interaction of Badrashboo essential oil with Nystatin indicated the synergistic effect of Badrashboo essential oil with Nystatin. Considering the significant antifungal effect observed for Badrashboo essential oil in the present study, it can be used in the food and pharmaceutical industries.

Subjects

ESSENTIAL oils; DISC diffusion tests (Microbiology); APPLE blue mold; FUSARIUM solani; NYSTATIN

Publication

Journal of Food Science & Technology (2008-8787), 2025, Vol 21, Issue 156, p226

ISSN

2008-8787

Publication type

Academic Journal

DOI

10.22034/FSCT.21.156.226.