Results
Title

Exploration of new platforms and potentials in regenerative medicine.

Authors

Štoković, Nikola; Ivanjko, Natalia; Pećin, Marko; Bordukalo, Tatjana; Kufner, Vera; Erjavec, Igor; Božić, Tamara; Milešević, Marina; Rumenović, Viktorija; Jelić, Ivona Matić; Blažević, Valentina; Smajlović, Ana; Capak, Hrvoje; Vrbanac, Zoran; Javor, Ana; Vnuk, Dražen; Oppermann, Hermann; Adanić, Dora; Perić, Mihaela; Matičić, Dražen

Abstract

Regenerative medicine is focused on the regeneration of various tissues and organs through the development of innovative therapeutic strategies and devices. Center of Excellence for Reproductive and Regenerative Medicine (CERRM) was established to provide necessary resources for conducting the state-of-the-art research in the field and to foster translation of developed therapeutic solutions to clinical practice. CERRM subunit for regenerative medicine has developed Osteogrow-C, a novel osteoinductive device for bone regeneration, which was successfully tested in various preclinical models including rabbit and sheep posterolateral spinal fusion (PLF) models as well as rabbit ulnar segmental defect model. Furthermore, CERRM has developed anti-BMP1.3 antibody-based therapy for various diseases that share fibrosis as a key pathological mechanism. This review paper provides the most important contemporary findings on the development of novel BMP-based devices for bone regeneration as well as the development of antifibrotic therapies.

Subjects

BONE regeneration; REGENERATIVE medicine; MORPHOGENESIS; REPRODUCTIVE health; ANIMAL models in research; SPINAL fusion

Publication

Rad Hrvatske Akademije Znanosti i Umjetnosti. Medicinske Znanosti, 2024, Vol 563, Issue 66/67, p48

ISSN

1330-5301

Publication type

Academic Journal

DOI

10.21857/m3v76t1j6y