Works matching Pharmacodynamics

Results: 5000

Pharmacodynamic model of dopamine D1 receptor agonists in the treatment of breast cancer lung metastasis.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2020, v. 29, n. 1, p. 45, doi. 10.5246/jcps.2020.01.004

By:

Liang Yang;
Ye Yao;
Yaoyao Feng;
Wei Lu;
Tianyan Zhou

Publication type:

Article

Mechanism-based pharmacokinetic/pharmacodynamic modeling of the effects of sitagliptin on DPP-4 activity, insulin and glucose in diabetic rats.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2018, v. 27, n. 6, p. 371, doi. 10.5246/jcps.2018.06.038

By:

Ye Yao;
Xiangfei Jiu;
Siyuan Wang;
Wei Lu;
Tianyan Zhou

Publication type:

Article

Population pharmacokinetics and pharmacodynamics of meropenem in Japanese pediatric patients.

Published in:

Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2010, v. 16, n. 2, p. 139, doi. 10.1007/s10156-009-0025-0

By:

Ikawa, Kazuro;
Morikawa, Norifumi;
Ikeda, Kayo;
Miki, Mizuka;
Kobayashi, Masao

Publication type:

Article

Pharmacodynamics of NOSO-502 studied in vitro and in vivo: determination of the dominant pharmacodynamic index driver.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 3, p. 752, doi. 10.1093/jac/dkae469

By:

van den Berg, Sanne;
Attwood, Marie G L;
Griffin, Pippa;
Sassen, Sebastiaan D T;
Muller, Anouk E;
Raaphorst, Merel N;
Gualtieri, Maxime;
Racine, Emilie;
Das, Shampa;
Noel, Alan R;
Meletiadis, Joseph;
MacGowan, Alasdair P

Publication type:

Article

Population pharmacokinetic-pharmacodynamic modelling to describe the effects of paracetamol and N-acetylcysteine on the international normalized ratio.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2015, v. 42, n. 1, p. 102, doi. 10.1111/1440-1681.12327

By:

Owens, Katie H;
Medlicott, Natalie J;
Zacharias, Mathew;
Whyte, Ian M;
Buckley, Nicholas A;
Reith, David M

Publication type:

Article

Characterization of Neutropenia in Advanced Cancer Patients Following Palbociclib Treatment Using a Population Pharmacokinetic-Pharmacodynamic Modeling and Simulation Approach.

Published in:

Journal of Clinical Pharmacology, 2017, v. 57, n. 9, p. 1159, doi. 10.1002/jcph.902

By:

Sun, Wan;
O'Dwyer, Peter J.;
Finn, Richard S.;
Ruiz‐Garcia, Ana;
Shapiro, Geoffrey I.;
Schwartz, Gary K.;
DeMichele, Angela;
Wang, Diane

Publication type:

Article

Plasma and cerebrospinal fluid concentrations of ibuprofen in pediatric patients and antipyretic effect: Pharmacokinetic-pharmacodynamic modeling analysis.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 9, p. 1023, doi. 10.1002/jcph.307

By:

Har‐Even, Ronly;
Stepensky, David;
Britzi, Malka;
Soback, Stefan;
Chaim, Adina Bar;
Brandriss, Norit;
Goldman, Michael;
Berkovitch, Matitiahu;
Kozer, Eran

Publication type:

Article

Population pharmacokinetic and pharmacodynamic modeling of different formulations of ONO-5334, cathepsin K inhibitor, in Caucasian and Japanese postmenopausal females.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 1, p. 23, doi. 10.1002/jcph.186

By:

Hasegawa, Chihiro;
Ohno, Tomoya;
Umemura, Takeo;
Honda, Naoki;
Ohyama, Michiyo;
Nagase, Shinichi;
Small, Maria;
Deacon, Steve;
Ogawa, Mikio;
Ieiri, Ichiro

Publication type:

Article

Population Pharmacokinetic and Pharmacodynamic Model-Based Comparability Assessment of a Recombinant Human Epoetin Alfa and the Biosimilar HX575.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 11, p. 1624, doi. 10.1177/0091270011421911

By:

Yan, Xiaoyu;
Lowe, Philip J.;
Fink, Martin;
Berghout, Alexander;
Balser, Sigrid;
Krzyzanski, Wojciech

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Newer Oral Cephalosporins: Implications for Treatment of Community-Acquired Lower Respiratory Tract Infections.

Published in:

Clinical Drug Investigation, 1998, v. 16, n. 4, p. 335, doi. 10.2165/00044011-199816040-00008

By:

Cazzola, M.;
Matera, M.G.;
Donner, C.F.

Publication type:

Article

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects.

Published in:

British Journal of Clinical Pharmacology, 2013, v. 75, n. 1, p. 197, doi. 10.1111/j.1365-2125.2012.04320.x

By:

Ali, Zahid;
Laurijssens, Bart;
Ostenfeld, Thor;
McHugh, Simon;
Stylianou, Anastasia;
Scott‐Stevens, Paul;
Hosking, Louise;
Dewit, Odile;
Richardson, Jill C.;
Chen, Chao

Publication type:

Article

The pharmacokinetic-pharmacodynamic model of telmisartan and hydrochlorothiazide on blood pressure and plasma potassium after long-term administration in spontaneously hypertensive rats.

Published in:

Fundamental & Clinical Pharmacology, 2015, v. 29, n. 6, p. 543, doi. 10.1111/fcp.12152

By:

Yu, Dan;
Chen, Yuancheng;
Hao, Kun

Publication type:

Article

Lamotrigine pharmacokinetic/pharmacodynamic modelling in rats.

Published in:

Fundamental & Clinical Pharmacology, 2005, v. 19, n. 6, p. 669, doi. 10.1111/j.1472-8206.2005.00380.x

By:

Castel-Branco, M. M.;
Falcão, A. C.;
Figueiredo, I. V.;
Caramona, M. M.

Publication type:

Article

Role of mechanistically-based pharmacokinetic/pharmacodynamic models in drug development : a case study of a therapeutic protein.

Published in:

2006

By:

Marshall, Scott;
Macintyre, Fiona;
James, Ian;
Krams, Michael;
Jonsson, Niclas E.

Publication type:

journal article

Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration.

Published in:

2005

By:

Mouton, Johan W.;
Vinks, Alexander A.

Publication type:

journal article

Pharmacokinetic-pharmacodynamic relationships of apomorphine in patients with Parkinson's disease.

Published in:

1999

By:

Neef, C.;
van Laar, T.

Publication type:

journal article

Achieving an optimal outcome in the treatment of infections. The role of clinical pharmacokinetics and pharmacodynamics of antimicrobials.

Published in:

1999

By:

Li, R.C.;
Zhu, M.;
Schentag, J.J.

Publication type:

journal article

Methodological issues in pharmacokinetic-pharmacodynamic modelling.

Published in:

1998

By:

Bellissant, E.;
Sébille, V.;
Paintaud, G.;
Sébille, V

Publication type:

journal article

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen.

Published in:

Pharmaceutics, 2020, v. 12, n. 11, p. 1049, doi. 10.3390/pharmaceutics12111049

By:

Loisios-Konstantinidis, Ioannis;
Cristofoletti, Rodrigo;
Jamei, Masoud;
Turner, David;
Dressman, Jennifer

Publication type:

Article

A direct comparison of the pharmacodynamic properties of insulin detemir and neutral protamine lispro insulin in patients with type 1 diabetes A direct comparison of the pharmacodynamic properties of insulin detemir and neutral protamine lispro insulin in patients with type 1 diabetes

Published in:

Diabetes, Obesity & Metabolism, 2013, v. 15, n. 3, p. 241, doi. 10.1111/dom.12016

By:

Korsatko, S.;
Glettler, K.;
Olsen, K. J.;
Wutte, A.;
Bock, G.;
Koehler, G.;
Mader, J. K.;
Semlitsch, B.;
Pieber, T. R.

Publication type:

Article

A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model.

Published in:

2018

By:

Wang, Taotao;
Zhang, Tao;
Meng, Ti;
Li, Ying;
Chen, Lu;
Yang, Qianting;
Dong, Haiyan;
Lei, Jin'e;
Chen, Limei;
Dong, Yalin

Publication type:

journal article

Pharmacokinetic–pharmacodynamic relationship of rocuronium under stable nitrous oxide–fentanyl or nitrous oxide–sevoflurane anesthesia in children.

Published in:

Pediatric Anesthesia, 2006, v. 16, n. 7, p. 761, doi. 10.1111/j.1460-9592.2005.01840.x

By:

Woloszczuk-Gebicka, Bogumila;
Wyska, Elzbieta;
Grabowski, Tomasz;
Świerczewska, Anna;
Sawicka, Renata

Publication type:

Article

Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential.

Published in:

2021

By:

de Jesus Antunes, Natalícia;
de Oliveira Filho, Raimundo Vieira;
de Oliveira Ilha, Jaime;
Moreno, Ronilson A.;
Nahoum, André Felipe;
Wedemeyer, Ralph-Steven;
Warnke, André;
De Nucci, Gilberto

Publication type:

journal article

Evaluation of the safety, pharmacodynamic, and pharmacokinetic effects following oral coadministration of immediate-release morphine with ethanol in healthy male participants.

Published in:

Human Psychopharmacology: Clinical & Experimental, 2014, v. 29, n. 3, p. 251, doi. 10.1002/hup.2394

By:

Setnik, Beatrice;
Sokolowska, Marta;
Johnson, Franklin;
Oldenhof, John;
Romach, Myroslava

Publication type:

Article

A two-part Phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 3, p. 631, doi. 10.1007/s00280-010-1534-3

By:

Mitchell, Claire;
O'Connor, J.;
Roberts, C.;
Watson, Y.;
Jackson, A.;
Cheung, S.;
Evans, J.;
Spicer, J.;
Harris, A.;
Kelly, C.;
Rudman, S.;
Middleton, M.;
Fielding, A.;
Tessier, J.;
Young, H.;
Parker, G.;
Jayson, G.

Publication type:

Article

Pharmacokinetic and pharmacodynamic study of two doses of bortezomib in patients with relapsed multiple myeloma.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 67, n. 1, p. 57, doi. 10.1007/s00280-010-1283-3

By:

Reece, Donna;
Sullivan, Dan;
Lonial, Sagar;
Mohrbacher, Ann;
Chatta, Gurkamal;
Shustik, Chaim;
Burris, Howard;
Venkatakrishnan, Karthik;
Neuwirth, Rachel;
Riordan, William;
Karol, Michael;
Moltke, Lisa;
Acharya, Milin;
Zannikos, Peter;
Keith Stewart, A.

Publication type:

Article

Population pharmacokinetic/pharmacodynamic modeling for the time course of tumor shrinkage by motesanib in thyroid cancer patients.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 6, p. 1151, doi. 10.1007/s00280-010-1456-0

By:

Jian-Feng Lu;
Claret, Laurent;
Sutjandra, Liviawati;
Kuchimanchi, Mita;
Melara, Rebeca;
Bruno, René;
Yu-Nien Sun

Publication type:

Article

Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 63, n. 6, p. 1035, doi. 10.1007/s00280-008-0828-1

By:

Bulitta, Jürgen B.;
Ping Zhao;
Arnold, Robert D.;
Kessler, Dean R.;
Daifuku, Richard;
Pratt, James;
Luciano, Gabriel;
Hanauske, Axel-R.;
Gelderblom, Hans;
Awada, Ahmad;
Jusko, William J.

Publication type:

Article

Interferon-gamma pharmacokinetics and pharmacodynamics in patients with colorectal cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2004, v. 53, n. 3, p. 253

By:

Turner, P. Kellie;
Houghton, Janet A.;
Petak, Istvan;
Tillman, David M.;
Douglas, Leslie;
Schwartzberg, Lee;
Billups, Catherine A.;
Panetta, John C.;
Stewart, Clinton F.

Publication type:

Article

Development of a schedule-dependent population pharmacodynamic model for rhizoxin without quantitation of plasma concentrations.

Published in:

2000

By:

Goh, Boon C.;
Fleming, Gini F.;
Janisch, Linda;
Vogelzang, Nicholas J.;
Stadler, Walter M.;
Ratain, Mark J.;
Goh, B C;
Fleming, G F;
Janisch, L;
Vogelzang, N J;
Stadler, W M;
Ratain, M J

Publication type:

journal article

A pharmacodynamic analysis method to determine the relative importance of drug concentration and treatment time on effect.

Published in:

Cancer Chemotherapy & Pharmacology, 2000, v. 45, n. 4, p. 265

By:

Millenbaugh, Nancy J.;
Guillaume Wientjes, M.;
Au, Jessie L.-S.

Publication type:

Article

Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review.

Published in:

Journal of Pharmacy & Pharmacology, 2019, v. 71, n. 4, p. 699, doi. 10.1111/jphp.13070

By:

Loisios‐Konstantinidis, Ioannis;
Paraiso, Rafael L. M.;
Fotaki, Nikoletta;
McAllister, Mark;
Cristofoletti, Rodrigo;
Dressman, Jennifer

Publication type:

Article

Evaluation of inhaled recombinant human insulin dry powders: pharmacokinetics, pharmacodynamics and 14‐day inhalation.

Published in:

Journal of Pharmacy & Pharmacology, 2019, v. 71, n. 2, p. 176, doi. 10.1111/jphp.13026

By:

He, Jiake;
Zhang, Ge;
Zhang, Qiuyang;
Chen, Jiayin;
Zhang, Yongjie;
An, Xiaoxia;
Wang, Pan;
Xie, Shan;
Fang, Fang;
Zheng, Jianheng;
Tang, Yue;
Zhu, Jiabi;
Yu, Yang;
Chen, Xijing;
Lu, Yang

Publication type:

Article

Enhancement of skin permeation of flurbiprofen via its transdermal patches using isopulegol decanoate ( ISO- C10) as an absorption enhancer: pharmacokinetic and pharmacodynamic evaluation.

Published in:

Journal of Pharmacy & Pharmacology, 2015, v. 67, n. 9, p. 1232, doi. 10.1111/jphp.12428

By:

Chen, Yang;
Quan, Peng;
Liu, Xiaochang;
Guo, Wenjia;
Song, Wenting;
Cun, Dongmei;
Wang, Zhongyan;
Fang, Liang

Publication type:

Article

Effect of Aqueous Root Extract of Decalepis hamiltonii on Lopinavir Pharmacokinetics and Midazolam Pharmacodynamics.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2024, v. 58, n. 2, p. 487, doi. 10.5530/ijper.58.2.54

By:

Sandopa, Dhanunjaya;
Vellapandian, Chitra

Publication type:

Article

Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling against Escherichia coli in Pigs.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00542

By:

Zhixin Lei;
Qianying Liu;
Jincheng Xiong;
Bing Yang;
Shuaike Yang;
Qianqian Zhu;
Kun Li;
Shishuo Zhang;
Jiyue Cao;
Qigai He

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Fungal Defensin NZX Against Staphylococcus aureus -Induced Mouse Peritonitis Model.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.865774

By:

Zheng, Xueling;
Yang, Na;
Mao, Ruoyu;
Hao, Ya;
Teng, Da;
Wang, Jianhua

Publication type:

Article

Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats.

Published in:

Psychopharmacology, 2021, v. 238, n. 12, p. 3629, doi. 10.1007/s00213-021-05981-x

By:

Bergh, Marianne Skov-Skov;
Bogen, Inger Lise;
Garibay, Nancy;
Baumann, Michael H.

Publication type:

Article

Safety, pharmacodynamics, and pharmacokinetics of multiple oral doses of delta-9-tetrahydrocannabinol in older persons with dementia.

Published in:

Psychopharmacology, 2015, v. 232, n. 14, p. 2587, doi. 10.1007/s00213-015-3889-y

By:

Ahmed, Amir;
Elsen, Geke;
Colbers, Angela;
Kramers, Cornelis;
Burger, David;
Marck, Marjolein;
Olde Rikkert, Marcel

Publication type:

Article

Design, statistical optimisation, characterisation and pharmacodynamic studies on Pioglitazone hydrochloride floating microparticles.

Published in:

Journal of Microencapsulation, 2014, v. 31, n. 4, p. 406, doi. 10.3109/02652048.2013.863399

By:

Rao, B. Prakash;
Baby, Beny;
Mathews, Rashmi;
Rajarajan, S.;
Haritha, Puri;
Ramesh, K.;
Gupta, N. Vijay Kumar

Publication type:

Article

Dose Optimization in Oncology Drug Development: The Emerging Role of Pharmacogenomics, Pharmacokinetics, and Pharmacodynamics.

Published in:

Cancers, 2023, v. 15, n. 12, p. 3233, doi. 10.3390/cancers15123233

By:

Papachristos, Apostolos;
Patel, Jai;
Vasileiou, Maria;
Patrinos, George P.

Publication type:

Article

A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics.

Published in:

Russian Journal of Numerical Analysis & Mathematical Modelling, 2015, v. 30, n. 5, p. 299, doi. 10.1515/rnam-2015-0027

By:

Tretyakova, Rufina M.;
Meyerhans, Andreas;
Bocharov, Gennady A.

Publication type:

Article

Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by Aspergillus flavus.

Published in:

2018

By:

Negri, Clara E.;
Johnson, Adam;
McEntee, Laura;
Box, Helen;
Whalley, Sarah;
Schwartz, Julie A.;
Ramos-Martín, V.;
Livermore, Joanne;
Kolamunnage-Dona, Ruwanthi;
Colombo, Arnaldo L.;
Hope, William W.

Publication type:

journal article

Lack of effect of lacosamide on the pharmacokinetic and pharmacodynamic profiles of warfarin.

Published in:

Epilepsia (Series 4), 2013, v. 54, n. 7, p. 1161, doi. 10.1111/epi.12192

By:

Stockis, Armel;
Lier, Jan Jaap;
Cawello, Willi;
Kumke, Thomas;
Eckhardt, Klaus

Publication type:

Article

Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers.

Published in:

Epilepsia (Series 4), 2013, v. 54, n. 3, p. 530, doi. 10.1111/epi.12085

By:

Cawello, Willi;
Rosenkranz, Bernd;
Schmid, Bernhard;
Wierich, Werner

Publication type:

Article

Laboratory Research Pharmacodynamic Analysis of the Anticonvulsant Effects of Tiagabine and Lamotrigine in Combination in the Rat.

Published in:

Epilepsia (Series 4), 2004, v. 45, n. 5, p. 424, doi. 10.1111/j.0013-9580.2004.50503.x

By:

Jonker, Danië M.;
Voskuyl, Rob A.;
Danhof, Meindert

Publication type:

Article

Pharmacodynamic dose adjustment in renal failure: importance of the Hill coefficient.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2006, v. 44, n. 10, p. 474, doi. 10.5414/CPP44474

By:

Czock, D.

Publication type:

Article

Simultaneous administration of vardenafil and alcohol does not result in a pharmacodynamic or pharmacokinetic interaction in healthy male subjects.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2006, v. 44, n. 5, p. 216, doi. 10.5414/CPP44216

By:

Wensing, G.;
Bauer, R.;
Unger, S.;
Rohde, G.;
Heinig, R.

Publication type:

Article

A pharmacodynamic model of the effects of controlled-onset extended-release verapamil on 24-hour ambulatory blood pressure.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2005, v. 43, n. 4, p. 187, doi. 10.5414/CPP43187

By:

Lima, J. J.;
Nhi Beasley, B.;
Parker, R. B.;
Johnson, J. A.

Publication type:

Article

Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent.

Published in:

Human Psychopharmacology: Clinical & Experimental, 2001, v. 16, n. 5, p. 369, doi. 10.1002/hup.310

By:

Patat, Alain;
Paty, Isabelle;
Hindmarch, Ian

Publication type:

Article