Assessment of Serum Level of Selenium and Zinc in Children with Dysfunctional Thyroid Disorders.

Abdelfatah Sallam, Lamia Farouk; Ibrahim, Mohamed Hassan; Alkholy, Usama Mahmoud; Pasha, Heba Fouad; Mohamed, Soma Abdallah

Background: There is biological plausibility to the link between trace element levels and thyroid hormone metabolism. While some studies found higher concentrations of trace elements in the blood of dysfunctional thyroid patients, others found lower levels. Therefore, it became mandatory to formulate an idea about the circulating levels of selected trace elements as selenium (Se) and zinc (Zn) in children with dysfunctional thyroid disorders. Aim: To investigate the association between dysfunctional thyroid disorders and selected trace elements Se and Zn concentrations in children. Methods: This study was a crosssectional study conducted at the pediatrics department and outpatient clinics of pediatric endocrinology unit, Zagazig University Hospital in the period of about 1.5 year. This study included 300 participants who were evaluated regarding thyroid function, 210 of them had proven dysfunctional thyroid disorder while 90 subjects were healthy individuals. Zn, Se, thyroid function and thyroid antibodies were measured in all children. Results: Regarding trace elements, acquired hypothyroidism group and congenital hypothyroidism group showed significant lower mean zinc level when compared to control group. Also acquired hypothyroidism group showed significantly lower mean Selenium level when compared to control group. Conclusion: Selenium and zinc deficiency was found in children who were found to have dysfunctional thyroid disorders.

THYROID diseases; CONGENITAL hypothyroidism; TRACE elements; PEDIATRIC endocrinology; PEDIATRIC clinics

Zagazig University Medical Journal, 2024, Vol 30, p4795

1110-1431

Academic Journal

10.21608/zumj.2024.274278.3228