Nano fat Injection versus Platelet Rich Plasma with Glutathione Injection in the Treatment of Post-Acne Scars.

Awad, Mohamed Salah; Gouda, Adham Mohammed; Saqr, Mohammed Adel

Background: Comedones, papules, nodules, and scars are the hallmarks of acne vulgaris. In patients who are prone to scarring, scarring is a common consequence. There appears to be an improvement in skin texture and structural volumization with injections of Nanofat mixed with microfat. Platelet-rich plasma use in regenerating damaged tissues has attained a lot of interest. Glutathione has remarkable antioxidant properties and a lightening effect. It has also been found to decrease wrinkles and increase skin elasticity. Glutathione is used as monotherapy or in combination with PRP. This study aimed to investigate nanofat in treating post-acne scars compared to platelet-rich plasma added to glutathione injections. Methods: This comparative clinical study included 24 patients complaining of post-acne scars, selected from the Plastic & Reconstructive Surgery Department, Zagazig University Hospitals. Nanofat injection treatment was applied on the right side of the face, and PRP with glutathione injection was used on the left side of the face. Results: Statistically significant differences were found between pre-and post-Goodman-Baron acne scar grading among the Nano-fat injection group and the PRP+ glutathione group (p=0.006,0.009, respectively). Post-inflammatory hyperpigmentation was significantly higher among the nanofat group (45.8%) than among the PRP+ glutathione group (12.5%) (p=0.01). Conclusions: Injection of Nanofat could be an effective scar treatment leading to statistically significant improvements in scar appearance, PRP injection in combination with glutathione is also an effective treatment in improvement of post acne scars appearance. These therapeutic procedures provide a valuable tool for every plastic surgeon.

PLATELET-rich plasma; WRINKLES (Skin); PLASTIC surgeons; GLUTATHIONE; ACNE

Zagazig University Medical Journal, 2024, Vol 30, p5113

1110-1431

Academic Journal

10.21608/ZUMJ.2024.279989.3292