Quality of Life in Patients with Systemic Lupus Erythematosus: Relation with Disease Activity, Severity and Fatigue.

Sherby, Nagwa Ahmad; Haleem Frere, Noha Osman Abdel; Kamel Elsayed, Rania Saber; Abdelhady, Enas Ibrahim

Background: The multisystem manifestations of Systemic lupus erythematosus (SLE) individuals greatly affect the patients, physical and psychological functioning and impair their capability to take part in work and social activities. This study aimed to explore SLE disease activity, severity and fatigue impacts on their quality of life (Qol). Methods: We conducted this cross-section study on 84 SLE patients who were defined as having SLE by the criteria established by the American College of Rheumatology (ACR) in its most recent revision. Assessment of fatigue factors was done via the multidimensional assessment of fatigue (MAF) questionnaire. QoL of the SLE cases was evaluated by the Arabic version of SLE QoL questionnaire. Results: The mean SLEDAS was 16.64±13.59 with (85.7%) of cases had HLDAS and the others (14.3%) had LLDAS. The mean SLEQoL score was 105.69±32.37 and the mean MAF score was 57.24±28.17. Statistically significant differences were found between lupus patients with HLDAS and those with LLDAS as regards fatigue and QoL. Patients with HLDAS group showed higher mean scores of MAF and SLEQoL while no statistically significant differences were found between patients with HLDAS and those with LLDAS as regards age, duration of disease and LSI. Conclusions: The inter-relationships between the assessment indices of activity, severity, fatigue and QoL were studied and revealed strong positive correlations between MAF and both SLEQoL and SLEDAS. There was a moderate positive correlation between SLEDAS and SLEQoL. There were weak positive correlations between LSI and each of the other indices (SLEQoL, SLEDAS and MAF). Multivariate logistic regression revealed that MAF was the only significant associated factor with SLE disease activity.

FATIGUE (Physiology); STATISTICAL significance; CANCER fatigue; SYSTEMIC lupus erythematosus; QUALITY of life; DISEASE duration

Zagazig University Medical Journal, 2024, Vol 30, p11

1110-1431

Academic Journal

10.21608/ZUMJ.2024.255642.3049