Phenotypic detection of multi-drug and extensively drug resistant Mycobacterium tuberculosis among tuberculosis patients in Kaduna State North West Nigeria.

Mamuda, Kasimu; Sani, Muhammad Aliyu; Olonitola, Olayeni Steven; Saraja, Ahmodu Opaluwa

Background: Tuberculosis (TB) is one of the leading infectious diseases that cause death worldwide; the emergence of drug resistant Mycobacterium tuberculosis is of great concern for TB control program in Nigeria. Aim and Objective: To detect multi-drug and extensively drug resistant Mycobacterium tuberculosis among Tuberculosis Patients in Kaduna State North west Nigeria. Study Design: This was a cross sectional study among tuberculosis patients attending Directly Observed Treatment Short Course (DOTS) clinics in the three (3) senatorial districts of Kaduna State, Nigeria. Material and Methods: A total of 360 presumptive drug resistant tuberculosis patients' samples were collected and decontaminated using modified Petroff method (NaOH-Na-citrate-NALC) from August 2018 to December 2020. Drug susceptibility testing was performed on first- and second-line anti-tuberculosis drugs for the 305 confirmed MTBC isolates using Lowenstein Jensen (LJ) Proportion Method. Results: A total of 67(21.8%) isolates were pan-susceptible, 176(57.5%) isolates were MDR-TB, Rifampicin and Isoniazid mono-resistant were 46(15.1%) and 17(5.6%) respectively. For the second line drugs, a total of 271(80.22%) isolates were found to be pan-susceptible and 35(19.88%) isolates were pre-extensively drug resistant TB. Conclusions: These findings established higher prevalence of MDR-TB and pre-extensively resistant TB in Kaduna state.

KADUNA (Nigeria); MULTIDRUG resistance in bacteria; TUBERCULOSIS; DISEASE prevalence; ANTITUBERCULAR agents

Microbes & Infectious Diseases, 2024, Vol 5, Issue 1, p148

2682-4132

Academic Journal

10.21608/MID.2023.219742.1552