Works matching DE "LIGANDS (Biochemistry)"

Results: 5000

Nickel nanomaterials as delivery system in combating diseases.

Published in:

Journal of Drug Delivery & Therapeutics, 2025, v. 15, n. 5, p. 166, doi. 10.22270/jddt.v15i5.7124

By:

Mandal, Ardhendu Kumar

Publication type:

Article

Advances in the Functionalization of Vaccine Delivery Systems: Innovative Strategies and Translational Perspectives.

Published in:

Pharmaceutics, 2025, v. 17, n. 5, p. 640, doi. 10.3390/pharmaceutics17050640

By:

de Moura, Ingrid Andrêssa;
Silva, Anna Jéssica Duarte;
de Macêdo, Larissa Silva;
Melo, Karina Mayumi Tani Bezerra de;
Leal, Lígia Rosa Sales;
Espinoza, Benigno Cristofer Flores;
Invenção, Maria da Conceição Viana;
Pinho, Samara Sousa de;
Freitas, Antonio Carlos de

Publication type:

Article

Efficient Delivery of SARS-CoV-2 Plasmid DNA in HEK-293T Cells Using Chitosan Nanoparticles.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 683, doi. 10.3390/ph18050683

By:

Mendoza-Guevara, Citlali Cecilia;
Martinez-Escobar, Alejandro;
Ramos-Godínez, María del Pilar;
Muñoz-Medina, José Esteban;
Ramon-Gallegos, Eva

Publication type:

Article

Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 607, doi. 10.3390/ph18050607

By:

Tanaka, Masaru;
Szatmári, István;
Vécsei, László

Publication type:

Article

Insights into Chemoreceptor MCP2201-Sensing D-Malate.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4902, doi. 10.3390/ijms26104902

By:

Cui, Rui;
Li, Jie;
Hong, Yuan;
Guo, Lu;
Wang, Yun-Hao;
Bai, Yi-Fei;
Li, De-Feng

Publication type:

Article

Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4890, doi. 10.3390/ijms26104890

By:

Chen, Xing;
Yang, Shu;
Shaw, Natalie D.;
Xia, Menghang

Publication type:

Article

Discovery and Functional Validation of EP3 Receptor Ligands with Therapeutic Potential in Cardiovascular Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4879, doi. 10.3390/ijms26104879

By:

Alonso-Fernández, Jorge-Ricardo;
Montoro-García, Silvia;
Cruz, Andreia-Filipa;
Ponce-Valencia, Alicia;
Carmena-Bargueño, Miguel;
Pérez-Sánchez, Horacio

Publication type:

Article

Identification of genetically engineered strategies to manipulate nano-platforms presenting immunotherapeutic ligands for alleviating primary ovarian insufficiency progression.

Published in:

Cell Communication & Signaling, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12964-025-02226-8

By:

Zhou, Guannan;
Gu, Yuanyuan;
Zhang, Menglei;
Ding, Jingxin;
Lu, Guanming;
Hua, Keqin;
Shen, Fang

Publication type:

Article

Identification of lung adenocarcinoma subtypes based on mitochondrial energy metabolism-related genes.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2025, v. 44, n. 7, p. 568, doi. 10.1080/15257770.2024.2369093

By:

Ding, Jianyang;
Chen, Keng;
Wu, Xuhui

Publication type:

Article

Bone Biology and the Role of the RANK Ligand Pathway.

Published in:

Oncology (08909091), 2009, v. 23, p. 9

By:

Murthy, Rashmi K.;
Morrow, P. K.;
Theriault, Richard L.

Publication type:

Article

Infusion Reactions to Monoclonal Antibodies for Solid Tumors: Immunologic Mechanisms and Risk Factors.

Published in:

Oncology (08909091), 2009, v. 23, n. 2, p. 14

By:

Chung, Christine H.;
O'Neil, Bert H.

Publication type:

Article

Molecular Targets on Blood Vessels for Cancer Therapies in Clinical Trials.

Published in:

Oncology (08909091), 2007, v. 21, n. 11, p. 1346

By:

Sato, Masanori;
Arap, Wadih;
Pasqualini, Renata

Publication type:

Article

Molecular prejudice: RNA discrimination against purines allows response to a cellular alarm.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 10, p. 754, doi. 10.1038/nsmb.3095

By:

Ruehle, Marisa D;
Kieft, Jeffrey S

Publication type:

Article

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 7, p. 522, doi. 10.1038/nsmb.3051

By:

Do Kwon, Young;
Pancera, Marie;
Acharya, Priyamvada;
Georgiev, Ivelin S;
Crooks, Emma T;
Gorman, Jason;
Joyce, M Gordon;
Guttman, Miklos;
Ma, Xiaochu;
Narpala, Sandeep;
Soto, Cinque;
Terry, Daniel S;
Yang, Yongping;
Zhou, Tongqing;
Ahlsen, Goran;
Bailer, Robert T;
Chambers, Michael;
Chuang, Gwo-Yu;
Doria-Rose, Nicole A;
Druz, Aliaksandr

Publication type:

Article

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 362, doi. 10.1038/nsmb.3014

By:

Kroeze, Wesley K;
Sassano, Maria F;
Huang, Xi-Ping;
Lansu, Katherine;
McCorvy, John D;
Giguère, Patrick M;
Sciaky, Noah;
Roth, Bryan L

Publication type:

Article

Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 1, p. 57, doi. 10.1038/nsmb.2929

By:

Gouridis, Giorgos;
Schuurman-Wolters, Gea K;
Ploetz, Evelyn;
Husada, Florence;
Vietrov, Ruslan;
de Boer, Marijn;
Cordes, Thorben;
Poolman, Bert

Publication type:

Article

Structural determinants of integrin β-subunit specificity for latent TGF-β.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 12, p. 1091, doi. 10.1038/nsmb.2905

By:

Dong, Xianchi;
Hudson, Nathan E;
Lu, Chafen;
Springer, Timothy A

Publication type:

Article

Evidence for a group II intron-like catalytic triplex in the spliceosome.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 5, p. 464, doi. 10.1038/nsmb.2815

By:

Fica, Sebastian M;
Mefford, Melissa A;
Piccirilli, Joseph A;
Staley, Jonathan P

Publication type:

Article

Conformational dynamics of ligand-dependent alternating access in LeuT.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 5, p. 472, doi. 10.1038/nsmb.2816

By:

Kazmier, Kelli;
Sharma, Shruti;
Quick, Matthias;
Islam, Shahidul M;
Roux, Benoît;
Weinstein, Harel;
Javitch, Jonathan A;
Mchaourab, Hassane S

Publication type:

Article

DNA is all the RAGE.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 11, p. 1242, doi. 10.1038/nsmb.2714

By:

Chen, Inês

Publication type:

Article

Defining the structural relationship between kainate-receptor deactivation and desensitization.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 9, p. 1054, doi. 10.1038/nsmb.2654

By:

Dawe, G Brent;
Musgaard, Maria;
Andrews, Elizabeth D;
Daniels, Bryan A;
Aurousseau, Mark R P;
Biggin, Philip C;
Bowie, Derek

Publication type:

Article

Unraveling the structural basis of GPCR activation and inactivation.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 5, p. 539, doi. 10.1038/nsmb.2584

By:

Bouvier, Michel

Publication type:

Article

Crystal structure of oligomeric β1-adrenergic G protein-coupled receptors in ligand-free basal state.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 419, doi. 10.1038/nsmb.2504

By:

Huang, Jianyun;
Chen, Shuai;
Zhang, J Jillian;
Huang, Xin-Yun

Publication type:

Article

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5? exonucleolytic degradation.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1324, doi. 10.1038/nsmb.2413

By:

Braun, Joerg E;
Truffault, Vincent;
Boland, Andreas;
Huntzinger, Eric;
Chang, Chung-Te;
Haas, Gabrielle;
Weichenrieder, Oliver;
Coles, Murray;
Izaurralde, Elisa

Publication type:

Article

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 7, p. 725, doi. 10.1038/nsmb.2332

By:

Shang, Guijun;
Zhu, Deyu;
Li, Ning;
Zhang, Junbing;
Zhu, Chunyuan;
Lu, Defen;
Liu, Cuilan;
Yu, Qian;
Zhao, Yanyu;
Xu, Sujuan;
Gu, Lichuan

Publication type:

Article

Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H+/Cl? exchanger.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 5, p. 525, doi. 10.1038/nsmb.2277

By:

Picollo, Alessandra;
Xu, Yanyan;
Johner, Niklaus;
Bernèche, Simon;
Accardi, Alessio

Publication type:

Article

ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 11, p. 1244, doi. 10.1038/nsmb.2135

By:

Low-Nam, Shalini T;
Lidke, Keith A;
Cutler, Patrick J;
Roovers, Rob C;
van Bergen en Henegouwen, Paul M P;
Wilson, Bridget S;
Lidke, Diane S

Publication type:

Article

Implications of molecular heterogeneity for the cooperativity of biological macromolecules.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 6, p. 732, doi. 10.1038/nsmb.2052

By:

Solomatin, Sergey V.;
Greenfeld, Max;
Herschlag, Daniel

Publication type:

Article

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 4, p. 437, doi. 10.1038/nsmb.2002

By:

Rizk, Shahir S.;
Paduch, Marcin;
Heithaus, John H.;
Duguid, Erica M.;
Sandstrom, Andrew;
Kossiakoff, Anthony A.

Publication type:

Article

Structural basis for selective activation of ABA receptors.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1109, doi. 10.1038/nsmb.1898

By:

Peterson, Francis C;
Burgie, E Sethe;
Park, Sang-Youl;
Jensen, Davin R;
Weiner, Joshua J;
Bingman, Craig A;
Chang, Chia-En A;
Cutler, Sean R;
Phillips, George N;
Volkman, Brian F

Publication type:

Article

Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1088, doi. 10.1038/nsmb.1869

By:

Drage, Michael G;
Tsai, Han-Chun;
Pecora, Nicole D;
Cheng, Tan-Yun;
Arida, Ahmad R;
Shukla, Supriya;
Rojas, Roxana E;
Seshadri, Chetan;
Moody, D Branch;
Boom, W Henry;
Sacchettini, James C;
Harding, Clifford V

Publication type:

Article

Identification and mechanism of ABA receptor antagonism.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 9, p. 1102, doi. 10.1038/nsmb.1887

By:

Melcher, Karsten;
Xu, Yong;
Ng, Ley-Moy;
Zhou, X Edward;
Soon, Fen-Fen;
Chinnusamy, Viswanathan;
Suino-Powell, Kelly M;
Kovach, Amanda;
Tham, Fook S;
Cutler, Sean R;
Li, Jun;
Yong, Eu-Leong;
Zhu, Jian-Kang;
Xu, H Eric

Publication type:

Article

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 4, p. 398, doi. 10.1038/nsmb.1782

By:

Seiradake, Elena;
Harlos, Karl;
Sutton, Geoff;
Aricescu, A. Radu;
Jones, E. Yvonne

Publication type:

Article

Allosteric regulation of Argonaute proteins by miRNAs.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 2, p. 144, doi. 10.1038/nsmb.1736

By:

Djuranovic, Sergej;
Zinchenko, Michelle Kim;
Hur, Junho K.;
Nahvi, Ali;
Brunelle, Julie L.;
Rogers, Elizabeth J.;
Green, Rachel

Publication type:

Article

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 1, p. 90, doi. 10.1038/nsmb.1721

By:

Haeger, Svenja;
Kuzmin, Dmitry;
Detro-Dassen, Silvia;
Lang, Niklas;
Kilb, Michael;
Tsetlin, Victor;
Betz, Heinrich;
Laube, Bodo;
Schmalzing, Günther

Publication type:

Article

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 7, p. 698, doi. 10.1038/nsmb.1607

By:

Bishop, Benjamin;
Aricescu, A. Radu;
Harlos, Karl;
O'Callaghan, Chris A.;
Jones, E. Yvonne;
Siebold, Christian

Publication type:

Article

Structural analysis of ion selectivity in the NaK channel.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 1, p. 35, doi. 10.1038/nsmb.1537

By:

Alam, Amer;
Youxing Jiang

Publication type:

Article

Structural basis for the activation of PPARγ by oxidized fatty acids.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 9, p. 924, doi. 10.1038/nsmb.1474

By:

Itoh, Toshimasa;
Fairall, Louise;
Amin, Kush;
Inaba, Yuka;
Szanto, Attila;
Balint, Balint L.;
Nagy, Laszlo;
Yamamoto, Keiko;
Schwabe, John W. R.

Publication type:

Article

Insights into PPARγ from structures with endogenous and covalently bound ligands.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 9, p. 893, doi. 10.1038/nsmb0908-893

By:

Nettles, Kendall W.

Publication type:

Article

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 8, p. 849, doi. 10.1038/nsmb.1457

By:

Cordle, Jemima;
Johnson, Steven;
Zi Yan Tay, Joyce;
Roversi, Pietro;
Wilkin, Marian B;
De Madrid, Beatriz Hernández;
Shimizu, Hideyuki;
Jensen, Sacha;
Whiteman, Pat;
Jin, Boquan;
Redfield, Christina;
Baron, Martin;
Lea, Susan M;
Handford, Penny A

Publication type:

Article

DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 5, p. 515, doi. 10.1038/nsmb.1414

By:

Garcin, Elsa D.;
Hosfield, David J.;
Desai, Sunil A.;
Haas, Brian J.;
Björas, Magnar;
Cunningham, Richard P.;
Tainer, John A.

Publication type:

Article

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 4, p. 422, doi. 10.1038/nsmb.1404

By:

Qing Huai;
Aiwu Zhou;
Lin Lin;
Mazar, Andrew P.;
Parry, Graham C.;
Callahan, Jennifer;
Shaw, David E.;
Furie, Bruce;
Furie, Barbara C.;
Mingdong Huang

Publication type:

Article

A monkey wrench in the kinase machine.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 12, p. 1120, doi. 10.1038/nsmb1207-1120

By:

Leahy, Daniel J.

Publication type:

Article

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 12, p. 1207, doi. 10.1038/nsmb1344

By:

Raghuram, Srilatha;
Stayrook, Keith R.;
Huang, Pengxiang;
Rogers, Pamela M.;
Nosie, Amanda K.;
McClure, Don B.;
Burris, Lorri L.;
Khorasanizadeh, Sepideh;
Burris, Thomas P.;
Rastinejad, Fraydoon

Publication type:

Article

Structure-based design of a pathway-specific nuclear import inhibitor.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 5, p. 452, doi. 10.1038/nsmb1229

By:

Cansizoglu, Ahmet E.;
Lee, Brittany J.;
Zi Chao Zhang;
Fontoura, Beatriz M. A.;
Yuh Min Chook

Publication type:

Article

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 5, p. 413, doi. 10.1038/nsmb1235

By:

Cunningham, David;
Danley, Dennis E.;
Geoghegan, Kieran F.;
Griffor, Matthew C.;
Hawkins, Julie L.;
Subashi, Timothy A.;
Varghese, Alison H.;
Ammirati, Mark J.;
Culp, Jeffrey S.;
Hoth, Lise R.;
Mansour, Mahmoud N.;
McGrath, Katherine M.;
Seddon, Andrew P.;
Shenolikar, Shirish;
Stutzman-Engwall, Kim J.;
Warren, Laurie C.;
Donghui Xia;
Xiayang Qiu

Publication type:

Article

Conformational restriction blocks glutamate receptor desensitization.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 12, p. 1120, doi. 10.1038/nsmb1178

By:

Weston, Matthew C.;
Schuck, Peter;
Ghosal, Alokesh;
Rosenmund, Christian;
Mayer, Mark L.

Publication type:

Article

Research Highlights.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 7, p. 575, doi. 10.1038/nsmb0706-575

By:

Barnett, Anna;
Konforti, Boyana;
Lall, Sabbi;
Schmidt, Tracy Smith

Publication type:

Article

Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 7, p. 611, doi. 10.1038/nsmb1110

By:

Ying Huang;
Bayfield, Mark A.;
Intine, Robert V.;
Maraia, Richard J.

Publication type:

Article

Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 6, p. 517, doi. 10.1038/nsmb1094

By:

Jansen, Joshua A;
McCarthy, Tom J;
Soukup, Garrett A;
Soukup, Juliane K

Publication type:

Article