The Impact of Opioid Receptor Gene Polymorphism on Fentanyl and Alfentanil's Analgesic Effects in the Pediatric Perioperative Period.

Lilic, Jelena; Marjanovic, Vesna G; Budic, Ivana; Stefanovic, Nikola; Stokanovic, Dragana; Marjanovic, Goran T; Jevtovic-Stoimenov, Tatjana; Golubovic, Mladjan; Zecevic, Maja; Velickovic-Radovanovic, Radmila

Introduction: The polymorphism of the gene coding mu-opioid receptor (OPRM1) is one of the factors contributing to the variability in the response to opioid analgesics in children. The goal of this study is to investigate its role in association with postoperative acute pain in children of various ages.Methods: This prospective study analyzed 110 pediatric patients, after plastic or orthopedic surgery, who were genotyped and randomly assigned to receive fentanyl or alfentanil. Postoperative pain was rated using Numerical Rating Scale (0– 10). All the patients were genotyped forOPRM1 118A>G (rs1799971) gene polymorphism.Results: School children under the age of 11 with the OPRM1 AA genotype were shown to have a higher BMI (pG polymorphism may explain the variation in the perception of postoperative pain in children over the age of 12 and may be a useful predictor for adjusting the dose of analgesics, but the dose is relative to the patient's needs regardless of his genetic characteristics. In younger children, carriers of polymorphic OPRM1 118G allele may be protected from obesity, due to diminished MOP expression.

Pharmacogenomics & Personalized Medicine, 2024, Vol 17, p41

1178-7066

Academic Journal

10.2147/PGPM.S443035