Indole Lactic Acid in Plasma and Urine: A Potential Biomarker for Chronic Kidney Disease and Inflammatory.

Hong, Hao; Zheng, Junyao; Shi, Haimin; Zhou, Suya; Chen, Yue; Li, Ming

aimin Shi,2 Suya Zhou,3 Yue Chen,4 Ming Li21Intensive Care Unit, the First Affiliated Hospital of Soochow University, Soochow, People's Republic of China; 2Laboratory Nephrology, the First Affiliated Hospital of Soochow University, Soochow, People's Republic of China; 3Laboratory Nephrology, Jinshan Hospital of Fudan University, Shanghai, People's Republic of China; 4Laboratory Nephrology, the First People's Hospital of Kunshan, Soochow, People's Republic of China *These authors contributed equally to this work Correspondence: Ming Li, Email [email protected] Purpose: We aimed to explore changes in plasma and urine indole lactic acid (ILA) levels and the relationship between inflammation and ILA in chronic kidney disease (CKD) patients and healthy people. Patients and Methods: Forty-seven CKD patients and 30 healthy individuals were included in this study. One-way ANOVA was used for variables with normal distribution and homogeneous variance. A rank-sum test was performed for non-normally distributed variables. Correlation analyses were performed using Pearson's or Spearman correlation analyses. Independent relationship between patients and CKD was analyzed using ordinal and binary logistic regressions. Receiver operating characteristic (ROC) curve was used. Results: Plasma and urine ILA levels were positively correlated (r = 0.51, P 0.01), urinary ILA (OR=2.14,P 0.01), urea levels (OR=1.43, P 0.01) and hemoglobin levels (OR=0.95, P 0.01) were significantly related. ROC curves indicated that plasma and urinary ILA were reliable predictors of CKD. CKD was correlated with plasma, urine ILA (OR=5.92, P 0.01; OR=2.79, P 0.01) and Hs-CRP (OR=2.45, P 0.01). Conclusion: Plasma and urine ILA can potentially be used as biomarkers of CKD and inflammatory status.

PEARSON correlation (Statistics); RECEIVER operating characteristic curves; LOGISTIC regression analysis; CHRONIC kidney failure; LACTIC acid

Journal of Inflammation Research, 2024, Vol 17, p4105

1178-7031

Academic Journal

10.2147/JIR.S458881