Results: 430
Zuojin Pill Alleviates Precancerous Lesions of Gastric Cancer by Modulating the MEK/ERK/c-Myc Pathway: An Integrated Approach of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5905, doi. 10.2147/DDDT.S487371
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- Publication type:
- Article
Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Erectile Dysfunction.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6243, doi. 10.2147/DDDT.S493198
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- Publication type:
- Article
Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Ruta graveolens L.: A Critical Review and Future Perspectives.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6459, doi. 10.2147/DDDT.S494417
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- Publication type:
- Article
Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling Pathway.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6313, doi. 10.2147/DDDT.S481714
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- Article
Levistolide a Attenuates Acute Kidney Injury in Mice by Inhibiting the TLR-4/NF-κB Pathway.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5583, doi. 10.2147/DDDT.S476548
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- Article
The Latest Progress in the Application of Telitacicept in Autoimmune Diseases.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5811, doi. 10.2147/DDDT.S493923
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- Article
The Effect of Intravenous Lidocaine on EC50 of Remifentanil for Preventing Cough During Emergence in Female for Thyroid Surgery Anesthesia.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6165, doi. 10.2147/DDDT.S496608
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- Article
The Clinical Efficacy of Gegen Qinlian Decoction in Treating Type 2 Diabetes is Positively Correlated with the Dose of Coptidis rhizoma: Three Randomized, Doubleblind, Dose-Parallel Controlled Clinical Trials.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5573, doi. 10.2147/DDDT.S487315
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- Article
OmpH is Involved in the Decrease of Acinetobacter baumannii Biofilm by the Antimicrobial Peptide Cec4.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5795, doi. 10.2147/DDDT.S481225
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- Article
Safety, Tolerability and Pharmacokinetics of Intravenous Sodium Taurodeoxycholate, HY209, a GPCR19 Agonist Inhibiting Inflammasomal Activation.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5853, doi. 10.2147/DDDT.S438507
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- Publication type:
- Article
Safety and Effectiveness of a Biosimilar Recombinant Growth Hormone in Adults with Growth Hormone Deficiency: Analysis of Final Data from PATRO Adults, an International Post-Marketing Surveillance Study.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5729, doi. 10.2147/DDDT.S471967
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- Publication type:
- Article
The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial [Response to Letter].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6221, doi. 10.2147/DDDT.S502748
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- Publication type:
- Article
Research Progress on the Anti-Liver Cancer Mechanism and Toxicity of Rhubarb Anthraquinone.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6089, doi. 10.2147/DDDT.S489377
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- Publication type:
- Article
Pharmacological Mechanisms of Cryptotanshinone: Recent Advances in Cardiovascular, Cancer, and Neurological Disease Applications.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6031, doi. 10.2147/DDDT.S494555
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- Publication type:
- Article
Recent Developments in Drug Design of Oral Synthetic Free Fatty Acid Receptor 1 Agonists.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5961, doi. 10.2147/DDDT.S487469
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- Publication type:
- Article
Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5709, doi. 10.2147/DDDT.S499037
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- Publication type:
- Article
Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6389, doi. 10.2147/DDDT.S487476
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- Publication type:
- Article
Pyroptosis the Emerging Link Between Gut Microbiota and Multiple Sclerosis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6145, doi. 10.2147/DDDT.S489454
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- Publication type:
- Article
Progress and Frontiers of Research on Dexmedetomidine in Perioperative Medicine: A Bibliometric Analysis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6017, doi. 10.2147/DDDT.S471602
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- Publication type:
- Article
Profile of Ofatumumab in the Treatment of Multiple Sclerosis: Design, Development and Place in Therapy.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5985, doi. 10.2147/DDDT.S315174
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- Publication type:
- Article
Prescribing Trends of Fixed-Dose Combination Antibiotics Not Recommended by the WHO (FNRs) for ICU Patients in Six Major Areas of China During a Seven-Year Period.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5781, doi. 10.2147/DDDT.S493980
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- Publication type:
- Article
Preoperative Anxiety's Impact on the Median Effective Dose of Esketamine for Alleviating Propofol Injection Pain in Patients Undergoing Painless abortion: A Randomized, Double-Blind, Controlled Trial.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5863, doi. 10.2147/DDDT.S482019
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- Publication type:
- Article
Portulaca Oleracea L. as a Potential Therapeutic Drug Intervention in Ulcerative Colitis: Mechanisms of Action and Clinical Studies.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5931, doi. 10.2147/DDDT.S486407
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- Publication type:
- Article
Population Pharmacokinetics and Dosing Regimen Analysis of Nirmatrelvir in Chinese Patients with COVID-19 Infection.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5517, doi. 10.2147/DDDT.S479561
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- Publication type:
- Article
Baolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6427, doi. 10.2147/DDDT.S499598
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- Publication type:
- Article
Panax notoginseng Saponins Improve Angiogenesis in Coronary Heart Disease Based on the microRNA 200a Methylation Pathway.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6075, doi. 10.2147/DDDT.S488036
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- Publication type:
- Article
Oxyresveratrol Alleviates Irinotecan-Induced Diarrhea and Enhances Antitumor Effects in Colorectal Cancer.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6283, doi. 10.2147/DDDT.S480179
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- Publication type:
- Article
Optimal Programmed Intermittent Epidural Bolus Interval Timing When Using 10 mL of 0.1% Ropivacaine and 0.5 mcg/mL Sufentanil for Labor Analgesia in Patients Without Breakthrough Pain: A Prospective, Randomized Study.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5563, doi. 10.2147/DDDT.S491054
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- Publication type:
- Article
Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6223, doi. 10.2147/DDDT.S486286
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- Publication type:
- Article
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6359, doi. 10.2147/DDDT.S482965
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- Publication type:
- Article
Magnetic-Powered Spora Lygodii Microrobots Loaded with Doxorubicin for Active and Targeted Therapy of Bladder Cancer.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5841, doi. 10.2147/DDDT.S490652
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- Publication type:
- Article
Potential Cardiovascular Risks Associated with Naltrexone-Bupropion Treatment in Overweight Patients [Letter].
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5793, doi. 10.2147/DDDT.S509093
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- Publication type:
- Article
Intrathecal Morphine and Ropivacaine for Quality of Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6133, doi. 10.2147/DDDT.S500316
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- Publication type:
- Article
Intraoperative Use of Sodium Bicarbonate Ringer's Solution Instead of Sodium Lactate Ringer's Solution to Reduce Endothelial Glycocalyx Degradation and Improve Postoperative Recovery During Cardiopulmonary Bypass Cardiac Surgery: A Single-Center Prospective Cohort Study
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5881, doi. 10.2147/DDDT.S501657
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- Publication type:
- Article
Intranasal Dexmedetomidine for the Management of Preoperative Anxiety-Related Insomnia: A Randomized, Three-Blinded, Clinical Trial Compared with Lorazepam and Placebo.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 6061, doi. 10.2147/DDDT.S487463
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- Publication type:
- Article
Unveiling the Mechanisms and Therapeutic Effects of Xiaoyao Sanjie Decoction in Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Approach.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 6263, doi. 10.2147/DDDT.S492047
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- Publication type:
- Article
Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan's Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague-Dawley Rats.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5641, doi. 10.2147/DDDT.S497212
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- Publication type:
- Article
Identification of Coumarin-Chalcone and Coumarin-Pyrazoline Derivatives as Novel Anti-Toxoplasma gondii Agents.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5599, doi. 10.2147/DDDT.S495089
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- Publication type:
- Article
Geraniol Ameliorates Pentylenetetrazol-Induced Epilepsy, Neuroinflammation, and Oxidative Stress via Modulating the GABAergic Tract: In vitro and in vivo studies.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5655, doi. 10.2147/DDDT.S481985
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- Publication type:
- Article
From the Formation of Conceptual Framework to Regulatory Decision-Making: Considerations for the Developments of Patient-Reported Outcome Instruments.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5759, doi. 10.2147/DDDT.S490289
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- Publication type:
- Article
Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6185, doi. 10.2147/DDDT.S496512
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- Publication type:
- Article
External Validation of the Population Pharmacokinetic Models of Amisulpride and Remedial Strategies for Delayed or Missed Doses.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 6345, doi. 10.2147/DDDT.S469149
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- Publication type:
- Article
Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer.
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- Drug Design, Development & Therapy, 2024, v. 18, p. 5615, doi. 10.2147/DDDT.S482340
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- Publication type:
- Article
Exploring the Effect and Mechanism of DaYuan Yin Against Acute Lung Injury by Network Pharmacology, Molecular Docking, and Experimental Validation.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5541, doi. 10.2147/DDDT.S491521
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- Publication type:
- Article
Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5529, doi. 10.2147/DDDT.S481481
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- Publication type:
- Article
EC<sub>50</sub> and EC<sub>95</sub> of Remifentanil for Inhibiting Bronchoscopy Responses in Elderly Patients During Fiberoptic Bronchoscopy Under Ciprofol Sedation: An Up-and-Down Sequential Allocation Trial.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 6487, doi. 10.2147/DDDT.S490907
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- Publication type:
- Article
Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5685, doi. 10.2147/DDDT.S485729
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- Publication type:
- Article
Effect of Remimazolam vs Midazolam on Early Postoperative Cognitive Recovery in Elderly Patients Undergoing Dental Extraction: A Prospective Randomized Controlled Study.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5895, doi. 10.2147/DDDT.S491223
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- Publication type:
- Article
Effect of Pretreatment with a Small Dose of Esketamine on Myoclonus Induced by Etomidate: A Randomized Controlled Trial.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 5773, doi. 10.2147/DDDT.S495130
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- Publication type:
- Article
Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid–Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial.
- Published in:
- Drug Design, Development & Therapy, 2024, v. 18, p. 6209, doi. 10.2147/DDDT.S492254
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- Publication type:
- Article