Similar Survival Between Non-Western Immigrant Patients and Danish-Born Patients with Lymphoma: A Danish Population-Based Study.

Simonsen, Mikkel Runason; Maksten, Eva Futtrup; Jakobsen, Lasse Hjort; Severinsen, Marianne Tang; Dann, Eldad J; Frederiksen, Henrik; Niemann, Carsten Utoft; Jørgensen, Judit Mészáros; Clausen, Michael Roost; Starklint, Jørn; Johnsen, Søren Paaske; El-Galaly, Tarec Christoffer; Baech, Joachim

Purpose: This nationwide Danish cohort study compared overall survival (OS) between non-Western immigrant patients and Danish-born patients with lymphoma in Denmark. Furthermore, differences in clinical and socioeconomic variables were compared, and mediators of OS differences were explored to explain possible outcome differences. Patients and Methods: The study included a total of 540 non-Western patients and 16,294 Danish-born patients diagnosed with lymphoma in the period 2000– 2020. Inverse probability weighting and mediation analysis using a natural effects Cox model were used to investigate the causal relationship between immigration status and OS. Results: Indirect effects mediated through differences in performance status and income indicated a trend towards inferior OS for non-Western immigrant patients with HRs of 1.06 (0.99– 1.14) and 1.06 (0.99– 1.14). However, no total causal effect of immigration status on OS was observed overall (HR: 0.94 [0.79– 1.12]) and within subtype-specific analyses, except for classical Hodgkin lymphoma. Conclusion: No significant differences in OS between non-Western immigrant patients and Danish-born patients were discovered. Plain Language Summary: Non-Western immigrant lymphoma patients in Western countries may face multiple challenges, including lower socioeconomic status and insufficient language proficiency, which can make navigating the complexity of modern lymphoma treatment difficult. This study investigated whether the Danish tax-based healthcare system has overcome these challenges and delivered non-Western immigrant patients quality care on the same levels as that of the Danish-born patients. Therefore, using available population based Danish registries, survival between these groups were compared, while adjusting for important clinical differences, and no significant effect of immigration status on survival was found even though non-Western immigrant patients generally had lower socioeconomic status.

HODGKIN'S disease; IMMIGRATION status; CAUSAL inference; SOCIOECONOMIC factors; WESTERN countries

Clinical Epidemiology, 2025, Vol 17, p19

1179-1349

Academic Journal

10.2147/CLEP.S484797