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Title

Adaptive response of resistant cancer cells to chemotherapy.

Authors

Yi-Jye Chern; Tai, Isabella T.

Abstract

Despite advances in cancer therapeutics and the integration of personalized medicine, the development of chemoresistance in many patients remains a significant contributing factor to cancer mortality. Upon treatment with chemotherapeutics, the disruption of homeostasis in cancer cells triggers the adaptive response which has emerged as a key resistance mechanism. In this review, we summarize the mechanistic studies investigating the three major components of the adaptive response, autophagy, endoplasmic reticulum (ER) stress signaling, and senescence, in response to cancer chemotherapy. We will discuss the development of potential cancer therapeutic strategies in the context of these adaptive resistance mechanisms, with the goal of stimulating research that may facilitate the development of effective cancer therapy.

Subjects

CANCER chemotherapy; CANCER cells; DRUG resistance in cancer cells; ENDOPLASMIC reticulum; AUTOPHAGY

Publication

Cancer Biology & Medicine, 2020, Vol 17, Issue 4, p842

ISSN

2095-3941

Publication type

Academic Journal

DOI

10.20892/j.issn.2095-3941.2020.0005

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