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- Title
Advances in biodegradable nanomaterials for photothermal therapy of cancer.
- Authors
Chao-Feng He; Shun-Hao Wang; He-Yun Shen; Hui-Ling Gao; Hui-Yu Liu; Ying-Jie Yu; Yan Zhao; Hai Wang; Lin-Lin Li
- Abstract
Photothermal cancer therapy is an alternative to chemotherapy, radiotherapy, and surgery. With the development of nanophotothermal agents, this therapy holds immense potential in clinical translation. However, the toxicity issues derived from the fact that nanomaterials are trapped and retained in the reticuloendothelial systems limit their biomedical application. Developing biodegradable photothermal agents is the most practical route to address these concerns. In addition to the physicochemical properties of nanomaterials, various internal and external stimuli play key roles on nanomaterials uptake, transport, and clearance. In this review, we summarized novel nanoplatforms for photothermal therapy; these nanoplatforms can elicit stimuli-triggered degradation. We focused on the recent innovative designs endowed with biodegradable photothermal agents under different stimuli, including enzyme, pH, and near-infrared (NIR) laser.
- Subjects
PHOTOTHERMAL spectroscopy; CANCER chemotherapy; NEAR infrared radiation; ALTERNATIVE treatment for cancer; BIODEGRADATION; NANOSTRUCTURED materials
- Publication
Cancer Biology & Medicine, 2016, Vol 13, p299
- ISSN
2095-3941
- Publication type
Academic Journal
- DOI
10.20892/j.issn.2095-3941.2016.0052