纳米酶在眼部疾病治疗中的研究进展.

刘 爽; 滕思莹; 惠 鹏; 孙雅彬

Moderate levels of reactive oxygen species (ROS) are essential in modulating a range of physiological processes in living organisms. An increase in ROS content can result in oxidative stress and harm to biological molecules, resulting in various diseases. Due to prolonged exposure to light, the eyes with high metabolic activity are especially vulnerable to oxidative stress, which is strongly associated with the onset and progression of various ophthalmic diseases. Therefore, it is crucial to eliminate ROS and maintain oxidation-reduction homeosta. With the progress of nanotechnology, nanozymes with enzyme-like activities, such as catalase (CAT) and superoxide dismutase (SOD), have attracted extensive attention due to their stability, ease of preparation, and good biocompatibility, in regulating oxidation-reduction homeosta and alleviating ROS-related damage. In this review, we systematically summarize the relationship between reactive oxygen species and ophthalmic diseases, the research progress of nanozymes in the treatment of ophthalmic diseases, and the challenges and difficulties in clinical translation.

REACTIVE oxygen species; BIOMOLECULES; SYNTHETIC enzymes; SUPEROXIDE dismutase; OXIDATIVE stress

Chinese Journal of Applied Chemistry, 2024, Vol 41, Issue 12, p1679

1000-0518

Academic Journal

10.19894/j.issn.1000-0518.240348