Based on a proton tumor treatment center, the full-scale model test of mass concrete was carried out by using a large amount of fly ash which was used to reduce the hydration heat and the high performance expansion anti-crack agent to prepare C35 shrinkage compensating concrete. The concrete construction process was strictly controlled, the temperature and strain were monitored and the application effect of mass concrete crack control was good. The results show that when the ambient temperature was 21-25 °C and the temperature of mixture placing to mold was about 30 °C, the maximum temperature inside the 4. 68 mx4. 68 mx4. 68 m full-scale model was 65.1 °C and temperature difference of core and surface was more than 25 °C; when the temperature difference between the surface temperature of the full-scale model and the ambient temperature was below 10 °C, the concrete was still in expansion state and the strain of the surface layer was 65. 9-219. 6µε.