Efficacy and safety of Weichang' an pill (胃肠安丸) combined with Western Medicine on gastrointestinal diseases: a systematic review and Meta-analysis.

WANG Jiabao; ZHANG Lishuang; NIU Baihan; YU Yajun; YANG Fengwen; MIAO Lin; CHAI Lijuan; DING Xinya; SUN Yingjie; WANG Yujing; WANG Lin; ZHANG Han; WANG Yi; LI Lin

OBJECTIVE: To systematically evaluate the efficacy and safety of Weichang'an pill (胃肠安丸, WCA) combined with Western Medicine (WM) for the treatment of gastrointestinal diseases. METHODS: Eight databases, including China National Knowledge Infrastructure Database, Wanfang Data, China Science and Technology Journal Database, SinoMed, PubMed, Web of Science, Cochrane Library, and Embase, were searched for randomized controlled trials (RCTs) of WCA from inception to 30 September 2021. We independently screened the literature, extracted data, and then evaluated the bias risk, effectiveness, safety, and other indicators of the included articles. RESULTS: A total of 33 RCTs were included in this study with 3368 patients. After analysis, it was found that WCA combined with WM could effectively prevent and treat antibiotic-associated gastrointestinal reaction, functional dyspepsia (FD), irritable bowel syndrome, rotavirus diarrhea (RVD), and ulcerative colitis (UC); no serious adverse reactions occurred. Moreover, compared with the control group, the experimental group showed significantly improved symptoms and some biochemical parameters. CONCLUSIONS: WCA combined with WM for the treatment of gastrointestinal diseases had better clinical efficacy than the control group, without serious adverse reactions. Notably, in the treatment of FD, RVD, and UC, WCA improved clinical symptoms and biochemical indicator expression. Nevertheless, owing to the restricted quality and quantity of the literature, the results need to be further studied using high-quality RCTs.

GASTROINTESTINAL diseases; PUBMED (Online service); WEB of Science (Web resource); RANDOMIZED controlled trials; META-analysis

Journal of Traditional Chinese Medicine, 2023, Vol 43, Issue 6, p1057

0255-2922

Academic Journal

10.19852/j.cnki.jtcm.20230814.003