丙二酰基人参皂苷对溃疡性结肠炎小鼠的 保护作用及其机制.

李嘉星; 王佳美; 李丹; 李美慧; 靳晓曼; 刘志

A ulcerative colitis （UC） model was established using dextran sulfate sodium （DSS）, and intervention with Malonyl Ginsenosides（ MGR） was employed. Biochemical markers in serum and colonic tissues of UC mice were measured, along with the expression of the PI3K/AKT/NF-κB signaling pathway in UC mice, and the alteration in intestinal microbiota was analyzed. Results revealed that MGR significantly decreased levels of IL-6, IL-1β, and TNF-α in serum, inhibited the elevation of MDA and MPO levels, and restored SOD levels in colonic tissues. Additionally, MGR downregulated the expression of p-PI3K, p-AKT, TLR4, and NF-κB. Furthermore, MGR modulated the composition and diversity of intestinal microbiota, reduced the relative abundance of harmful bacteria such as Desulfovibrionaceae, Parasutterella, and Helicobacter, while increased that of beneficial bacteria like Prevotellaccae and Lactobacillus. In conclusion, MGR may exert its anti-UC effects by suppressing inflammation, oxidative stress, and rebalancing intestinal microbiota.

GUT microbiome; ULCERATIVE colitis; BIOMARKERS; DEXTRAN sulfate; SODIUM sulfate

China Food Additives, 2024, Vol 35, Issue 12, p46

1006-2513

Academic Journal

10.19804/j.issn1006-2513.2024.12.006