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- Title
4-正丙基苯甲醛的合成及工艺优化.
- Authors
张斌; 冀士悦; 望雯静; 江丽君; 潘洁
- Abstract
4-Propylbenzaldehyde (C10H12O) 15 an important intermediate for pharmaceutical. At present, the primary manufacturing technique is extraction from Tsaoko. Therefore, it is urgent to develop an efficient, environmentally friendly and secure production process. In this research, 4-propylbenzoic acid was utilized as the raw material, through a sequence of three procedures, which is esterification, reduction, and oxidation reaction to achieve the final product. The products were qualitatively analyzed by IR and 'H-NMR, and quantitatively analyzed by GC. The structure and purity of the standard samples and the intermediate samples were determined. In addition, we optimized the reaction parameters of the synthesis process and speculated the corresponding reaction mechanism. Following the optimized conditions, the best yield of the three-step reaction were 95.2%, 91.0% and 66.7% respectively, and the overal yield of the whole process route was 57.8%.
- Subjects
CHEMICAL yield; ESTERIFICATION; MANUFACTURING processes; CHEMICAL kinetics; EXTRACTION techniques
- Publication
Journal of Central China Normal University, 2024, Vol 58, Issue 6, p654
- ISSN
1000-1190
- Publication type
Academic Journal
- DOI
10.19603/j.cnki.1000-1190.2024.06.005