4-正丙基苯甲醛的合成及工艺优化.

张斌; 冀士悦; 望雯静; 江丽君; 潘洁

4-Propylbenzaldehyde (C10H12O) 15 an important intermediate for pharmaceutical. At present, the primary manufacturing technique is extraction from Tsaoko. Therefore, it is urgent to develop an efficient, environmentally friendly and secure production process. In this research, 4-propylbenzoic acid was utilized as the raw material, through a sequence of three procedures, which is esterification, reduction, and oxidation reaction to achieve the final product. The products were qualitatively analyzed by IR and 'H-NMR, and quantitatively analyzed by GC. The structure and purity of the standard samples and the intermediate samples were determined. In addition, we optimized the reaction parameters of the synthesis process and speculated the corresponding reaction mechanism. Following the optimized conditions, the best yield of the three-step reaction were 95.2%, 91.0% and 66.7% respectively, and the overal yield of the whole process route was 57.8%.

CHEMICAL yield; ESTERIFICATION; MANUFACTURING processes; CHEMICAL kinetics; EXTRACTION techniques

Journal of Central China Normal University, 2024, Vol 58, Issue 6, p654

1000-1190

Academic Journal

10.19603/j.cnki.1000-1190.2024.06.005