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- Title
Pharmacodynamic Experiment of Dachengqi Decoction and Separated Decoction on Incomplete Intestinal Obstruction in Rats.
- Authors
Jiangeun WEI; Xiumei MA; Bing QING; Meiyan QIU; Qingmei DENG; Hong LEI; Zengyan YANG; Zujie QIN
- Abstract
[Objectives] To investigate the effect and mechanism of Dachengqi Decoction and separated decoction on incomplete intestinal obstruction in rats. [Methods] 80 healthy SD rats were selected to establish incomplete intestinal obstruction model by silk ligation. The dosage was 20 mL/kg for 3 d, and the damage index of ileocecal mucosa was analyzed; the morphology of ileocecal mucosa was observed by HE staining; the serum levels of IL-1 a, IL-lß, IL-6, IL-18, Ach, NO, ET, IL-1, TNF-a and ultra-micro Na'-K'-ATPase were detected by ELISA. [Results] Compared with the model group, the mucosal damage index of Dachengqi Decoction and each separated decoction group decreased significantly (P <0.05); compared with the normal group and sham operation group, the serum level of IL-1, IL-6, TNF-a and other factors in the model group increased significantly (P <0.05); compared with the model group, the serum IL-1, IL-6 and TNF-a secretion levels of rats in Dachengqi Decoction group and separated decoction group decreased (P <0.01). [Conclusions] Dachengqi Decoction and each separated decoction can effectively improve intestinal tissue pathological damage in the incomplete intestinal obstruction model rats, and reduce the inflammatory' reaction in the rat body.
- Subjects
BOWEL obstructions; LABORATORY rats; INTERLEUKIN-1; INTERLEUKIN-6; RATS
- Publication
Medicinal Plant, 2024, Vol 15, Issue 4, p107
- ISSN
2152-3924
- Publication type
Academic Journal
- DOI
10.19600/j.cnki.issn2152-3924.2024.04.024