Results
Title

Lyophilization Process of Hydroxypropyl Tetrahydropyrantriol Liposomes.

Authors

Shengqian TIAN; Enlong WANG; Xin ZHANG; Lili HE

Abstract

[Objectives] To enhance the skin permeability of hydroxypropyl tetrahydropyrantriol and provide a reference for the subsequent prevention or treatment of skin aging. [Methods] The lyophilization process of hydroxypropyl tetrahydropyrantriol liposomes was investigated using a single factor method, and a quality evaluation system was established based on the appearance, particle size, PD1, and re-dispersibility of the lyophilized samples. [Results] The lyophilization process of hydroxypropyl tetrahydropyrantriol liposomes was determined by single factor experiments. The pre-freezing period was 16 h at -80 A, the total drying time was 36 h, and the addition of 10% mannitol-sucrose was used as the lyoprotectant. [Conclusions] The product prepared by the lyophilization method exhibits a fluffy and full appearance, with minimal shrinkage and collapse. The volume remains consistent before and after lyophilization, and the re-dispersibility is satisfactory. The re-dissolution process is rapid, and the particle size and polydispersity index (PDI) remain largely unchanged before and after lyophilization.

Subjects

SKIN permeability; SKIN aging; FREEZE-drying; LIPOSOMES

Publication

Medicinal Plant, 2024, Vol 15, Issue 4, p35

ISSN

2152-3924

Publication type

Academic Journal

DOI

10.19600/j.cnki.issn2152-3924.2024.04.009