Action Mechanism of Components from Gardenia jasminoides on Eye Skin Based on Network Pharmacology.

Lu CHEN; Yingbing HE; Quan SHI; Xiaolan WANG

[Objectives] To explore the pharmacological effects of Gardenia jasminoides and its potential benefits on eye skin. [Methods] TCMSP and SymMap databases were used to screen the active components and corresponding targets of G. jasminoides. Human eye skin-related targets were screened, and the active component-target network and protein-protein interaction (PPI) network were established. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed. [Results] Twenty-six active compounds were screened out from G. jasminoides, and 277 targets were obtained. From the Gencards database, 26 652 disease targets were retrieved and 205 related gene targets were screened. The active component-action target network of G. jasminoides constructed by Cytoscape software revealed the potential of G. jasminoides to play a role in multiple biological pathways. In addition, PPI-network analysis, GO function analysis and KEGG pathway enrichment analysis revealed that the active components of G. jasminoides mainly regulate the biological processes such as inflammatory response, oxidative stress and apoptosis, involving MAPK, NF-kB and other important signaling pathways. [Conclusions] This study provides a theoretical basis for the eye skin protection of G. jasminoides and an important clue for future drug development.

EYE protection; DRUG development; PROTEIN-protein interactions; CELLULAR signal transduction; GENE targeting

Medicinal Plant, 2024, Vol 15, Issue 4, p20

2152-3924

Academic Journal

10.19600/j.cnki.issn2152-3924.2024.04.005