Exploring the Mechanism of Action of Gastrodin in Parkinson's Disease Based on Network Pharmacology.

Feifan LIU; Shifang LUO; Yan WAN; Linao ZHANG; Xue WU; Yuhuan XIE; Peixin GUO

[Objectives] To explore the mechanism of action of gastrodin in the treatment of Parkinson's disease (PD) by employing network pharmacology technology, and to provide a scientific theoretical basis for the rational clinical application of gastrodin. [Methods] The target of gastrodin was identified through a search of the SwissTargetPrediction database. The keyword "Parkinson Disease" was employed to identify the pertinent targets of PD in the GeneCards and OMIM databases. The relationship between gastrodin and PD was elucidated, and a Veen map was constructed to identify the genes that were common to both. A total of 52 common drug targets associated with PD as identified in the Wayne chart were imported into the String database (https://string-db. org/) for protein-protein interaction prediction. Subsequently, Cytoscape 3.9.1 software was employed to construct a "drug-target" network. The potential targets of gastrodin in the treatment of PD were then imported into the DAVID database, where GO analysis and KEGG enrichment results were obtained. [Results] A total of 22 core targets and 53 related pathways of gastrodin were identified as potentially beneficial for the treatment of PD. [Conclusions] Gastrodin may be a potential therapeutic agent for the treatment of PD by modulating the biological process of apoptosis, affecting the relevant pathways such as the IL-17 signaling pathway and the TNF signaling pathway, and acting on GAPDH, EGFR, CASP3, MMP9 and other targets.

PARKINSON'S disease; CELLULAR signal transduction; DATABASES; PROTEIN-protein interactions; DRUG target

Medicinal Plant, 2024, Vol 15, Issue 4, p16

2152-3924

Academic Journal

10.19600/j.cnki.issn2152-3924.2024.04.004