In order to investigate the dyeing performance of plant dyes on nylon/spandex knitted fabrics a plant dye extracted from pomegranate peel and pomegranate flower was used to dye nylon/spandex knitted fabrics. The effects of dyeing temperaturey pH value of dyeing solution, dyeing bath ratio and dye dosage on the dyeing performance of nylon/spandex knitted fabrics were analyzed, the dyeing rate of plant dyes on nylon/spandex knitted fabrics was analyzed > and the dyeing process was optimized* The optimized dyeing process was as follows: dyeing temperature 98 七, dye solution pH value 4, bath ratio 1 :10, holding time 40 min. To ensure the uniformity of tke dyeing the temperature should, be slowly increased between 60-98 X by 0* 5-1.0 °C/min. The optimized process was applied to the production of large goods, and the color fastness and antimicrobial property of the dyed fabrics were tested. The dyed, fairies have no uneven dyeing problems and the color difference of the CIE DE is only 0. 32 compared with the standard samples, the color fastness to soap washing and. rubbing is 4-5, the inhibition rate of Staphylococcus aureus and Escherichia coli is more than 98%, and the satisfactory dyeing effect is obtained.