Lipid-Based Nano-Formulation Development to Enhance Oral Bioavailability of Weakly Aqueous-Soluble Drug for Obesity and Hypertension.

Akhtar, Naseem; Ullah, Zabih; Khan, Mohd Faiyaz; Jain, Vicky; Bijani, Sabera; Choudhary, Ranjay Kumar; Ahmad, Nabeel; Rizvi, Moattar Raza; Iqbal, Danish

The most practical method of drug delivery is oral administration because it has a high rate of patient compliance. However, there are significant obstacles to effective oral medication delivery, including low drug enzymatic/metabolic stability and poor water solubility. Especially in the development of drug formulations for the treatment of obesity and hypertension. This research article aims to formulate solid lipid nanoparticles (SLN) of Fucoxanthin and Ramipril by the emulsification and ultrasonication methods. The nanoparticles size, polydispersity index, and the zeta potential, among other parameters, were computed. In addition, FT-IR analysis of compatibility tests between the SLNs and the loaded drug and in vitro drug release experiments were carried out. Lipid-based nano preparations have drawn plenty of interest as efficient vehicles to increase the oral bioavailability of these kinds of medications. We observed that lipid nanoparticles, have enhanced the oral bioavailability of poorly water-soluble drugs used for obesity and hypertension. Provided the above information, formulated SLNs should be further investigated using cutting-edge scientific methodologies to improve its bioavailability.

DRUG solubility; SCIENTIFIC method; ORAL drug administration; BIOAVAILABILITY; NANOPARTICLE size; ORAL medication

Journal of Advanced Zoology, 2023, Vol 44, p1777

0253-7214

Academic Journal

10.17762/jaz.v44is-5.1457